IL-10 and TNFalpha genotypes in SLE.

Journal of Biomedicine & Biotechnology
Patricia LópezAna Suárez

Abstract

The production of two regulators of the inflammatory response, interleukin 10 (IL-10) and tumor necrosis factor alpha (TNFalpha), has been found to be deeply deregulated in SLE patients, suggesting that these cytokines may be involved in the pathogenesis of the disease. Genetic polymorphisms at the promoter regions of IL-10 and TNFalpha genes have been associated with different constitutive and induced cytokine production. Given that individual steady-state levels of these molecules may deviate an initial immune response towards different forms of lymphocyte activation, functional genetic variants in their promoters could influence the development of SLE. The present review summarizes the information previously reported about the involvement of IL-10 and TNFalpha genetic variants on SLE appearance, clinical phenotype, and outcome. We show that, in spite of the heterogeneity of the populations studied, the existing knowledge points towards a relevant role of IL-10 and TNFalpha genotypes in SLE.

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Citations

Aug 6, 2013·Inflammation·Mehrdad HajilooiMohammad Momeni
Nov 10, 2013·PloS One·Patricia LópezAna Suárez
Mar 21, 2012·Critical Reviews in Immunology·Shankar Subramanian Iyer, Gehong Cheng
Jun 6, 2012·Journal of Biomedicine & Biotechnology·Martina Perše, Anton Cerar
Jun 2, 2012·Journal of Biomedicine & Biotechnology·John J Connolly, Hakon Hakonarson
Nov 6, 2015·Mediators of Inflammation·Sylvie HermouetBetty Gardie
Jan 4, 2018·Genetic Testing and Molecular Biomarkers·Irena ManolovaSpaska Stanilova
Mar 13, 2012·Contact Dermatitis·Lilla LandeckSwen M John
Oct 12, 2012·Molecular Biology Reports·Hai-Feng PanDong-Qing Ye
Jan 9, 2014·Inflammation·Hamid HakimiMohammad Kazemi Arababadi
Oct 27, 2016·Scandinavian Journal of Immunology·J H JungS J Choi
Feb 13, 2021·International Journal of Molecular Sciences·Anaïs AmendNina Chevalier

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