IL-10 inhibits neuraminidase-activated TGF-β and facilitates Th1 phenotype during early phase of infection

Nature Communications
Avijit DuttaYueh-Chia He

Abstract

Th1 cells control their activity by producing regulatory IL-10. Here we report that Th1 cell-derived IL-10 facilitates their expansion and, in addition, augments Th1 cell production of IFN-γ, TNF-α and IL-2 during the early phase of influenza. In our antigen-specific mouse experimental system, influenza haemagglutinin-specific CD4(+) T cells respond to infection with the induction of T-bet, and produce both IFN-γ and IL-10. In the early phase of infection, an abundance of viral neuraminidase causes TGF-β activation of haemagglutinin-specific CD4(+) T cells. CD4(+) T-cell-derived IL-10 inhibits neuraminidase-driven TGF-β activation and counteracts the virus-mediated immune suppression. As the host eradicates the virus, neuraminidase activity wanes and IL-10 receptors are upregulated on CD4(+) T cells in the late phase of infection. IL-10 then suppresses immune activation and aids in recovery from infection and inflammation. These results reveal a previously unrecognized function of Th1 cell-derived IL-10 in vivo.

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Citations

Apr 19, 2016·PloS One·Tony MarionKlaus Schughart
Jun 25, 2017·Scientific Reports·Ching-Tai HuangAvijit Dutta
Jan 30, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Luciana P TavaresRemo C Russo
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Jul 11, 2018·Frontiers in Immunology·Meredith J CraneAmanda M Jamieson
Sep 11, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Monty MazerKenneth E Remy
Sep 26, 2020·Frontiers in Cellular and Infection Microbiology·Kayla Frank, Silke Paust
Jun 12, 2020·Cell Communication and Signaling : CCS·Zhujiang DaiDaorong Wang
May 31, 2017·Seminars in Immunopathology·Xi-Zhi J Guo, Paul G Thomas
Feb 10, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zhifang ChenJianbing Ding
Mar 9, 2021·Frontiers in Cellular and Infection Microbiology·Ashleigh R Murphy-Schafer, Silke Paust

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