PMID: 15240669Jul 9, 2004Paper

IL-10 plays an important role in the homeostatic regulation of the autoreactive repertoire in naive mice

The Journal of Immunology : Official Journal of the American Association of Immunologists
Ana C AndersonVijay K Kuchroo

Abstract

We have previously shown that naive SJL (H-2(s)) mice, which are highly susceptible to myelin proteolipid protein (PLP)-induced experimental autoimmune encephalomyelitis (EAE), have a very high frequency (1/20,000 CD4 T cells) of PLP(139-151)-reactive T cells in the naive repertoire. In this study, we examine the function of this endogenous PLP(139-151)-reactive repertoire in vivo and find that this repertoire encompasses the precursors of pathogenic T cells. Because SJL mice do not develop spontaneous EAE, we have explored the mechanisms that keep this autopathogenic repertoire in check and prevent the development of spontaneous autoimmunity. We crossed IL-4 and IL-10 deficiency onto the SJL background and analyzed the roles of these two immunoregulatory cytokines in regulating the size and effector function of the endogenous PLP(139-151)-reactive repertoire and development of autoimmune disease. We find that IL-10 is important in the homeostatic regulation of the endogenous PLP(139-151)-reactive repertoire in that it both limits the size of the repertoire and prevents development of effector autoaggressive T cells. SJL IL-10(-/-) mice with high numbers of PLP(139-151)-specific precursors in the repertoire did not develop spon...Continue Reading

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Citations

Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Teun GuichelaarFemke Broere
Sep 24, 2010·Genes and Immunity·C C WallineJ J Bright
Oct 28, 2019·Frontiers in Cellular Neuroscience·Björn LafferMaren Kasper
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Narender NathInderjit Singh
Aug 10, 2005·Proceedings of the National Academy of Sciences of the United States of America·Divya J MekalaTerrence L Geiger
Sep 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mary RieckJane H Buckner
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel C BullardScott R Barnum
Nov 17, 2011·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Helena BatoulisStefanie Kuerten
Aug 12, 2017·Critical Reviews in Food Science and Nutrition·Hamid MollazadehAmirhossein Sahebkar
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Divya J MekalaTerrence L Geiger
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hong ZhangStephen D Miller
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel C BullardScott R Barnum
Jul 8, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Inna V GrishkanAnne R Gocke

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