IL-10 Producing B Cells Ability to Induce Regulatory T Cells Is Maintained in Rheumatoid Arthritis

Frontiers in Immunology
Julie MielleClaire Daien

Abstract

Despite growing evidence highlighting the relevance of increasing IL-10-producing B cells (B10+cells) in autoimmune diseases, their functions in patients are still unknown. The aim of this study was to evaluate the functions of CpG-induced B10+ cells isolated from healthy controls (HC) and rheumatoid arthritis (RA) patients, on naïve T cell differentiation. We demonstrated that CpG-induced B10+ cells from HC drove naïve T cell differentiation toward regulatory T cells (Treg cells) and IL-10-producing T cells (Tr1) through IL-10 secretion and cellular contacts. B10+ cells from HC did not decrease T helper 1 (Th1) nor and tumor necrosis factor α producing T cell (TNFα+ T cell) differentiation. We showed that in RA, B10+ cells could also induce Treg cells and Tr1 from naïve T cells. Contrary to HC, B10+ cells from RA patients increased naïve T cell conversion into Th1. Interestingly, PD-L2, a programmed death-1 (PD-1) ligand that inhibits PD-L1 and promotes Th1 differentiation, was overexpressed on RA B10+ cells compared to HC B10+ cells. Together, our findings showed that CpG-induced B10+ cells may be used to increase Treg cells in patients with RA. However, CpG may not be the most adequate stimuli as CpG-induced B10+ cells also ...Continue Reading

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Citations

Jan 23, 2019·Journal of Cellular Physiology·Xi JiaJin-An Zhang
Jul 13, 2019·Journal of the American Society of Nephrology : JASN·Taishi FangJaeseok Yang
Aug 19, 2020·Immunotherapy·Mary AlbrethsenJohn Nemunaitis
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Jun 11, 2021·Frontiers in Immunology·Wang LongHelong Dai

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Methods Mentioned

BETA
FACS
PMA
flow cytometry
ELISA
Assay

Software Mentioned

FlowJo
Graph Pad Prism

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