IL-10-producing B cells play important role in the pathogenesis of recurrent pregnancy loss.

International Immunopharmacology
Shahla DanaiiMehdi Yousefi

Abstract

Interleukin (IL)-10-producing B cells are recently known for their regulatory function in several disorders. However, the possible role of these cells remains unclear in recurrent pregnancy loss (RPL) pathogenesis. Total B cells from 24 RPL patients with cellular immune abnormalities, as well as that of 25 normal pregnant women were cultured and stimulated by Toll Like Receptor (TLR) agonists (CpG oligodeoxynucleotides (ODN) and imiquimod). Then, the frequency of IL-10+ CD19+ B cells was found out using flow cytometry. Enzyme-linked immunosorbent assay (ELISA) was used to assess the levels of IL-10 in supernatant medium and serum of stimulated B cells, as well as those of several serum autoantibodies. Real-Time PCR method was carried out for determining the IL-10 expression level and specific genes transcripts. RPL patients indicated a lower proportion of IL-10+ CD19+ B cells, and reduced levels of IL-10 in both serum and supernatant of the culture medium of the stimulated B cells. According to the results, total IgG levels was greater in serum of RPL patients in comparison with healthy pregnant women. Similarly, the percentage of these cells was negatively correlated with serum total IgG levels and the number of miscarriages. ...Continue Reading

Citations

Apr 9, 2021·Immunological Investigations·Yousef YousefzadehMehdi Yousefi
May 18, 2021·Frontiers in Immunology·Diego CatalánOctavio Aravena
May 28, 2021·American Journal of Reproductive Immunology : AJRI·Mohammad Ali ZolfaghariMehdi Yousefi
Jun 22, 2021·Critical Reviews in Food Science and Nutrition·Amin AbbasiAziz Homayouni-Rad
Jul 26, 2021·International Immunopharmacology·Leila Mohamed KhosroshahiLeili Aghebati-Maleki
Aug 14, 2021·Klinicheskaia laboratornaia diagnostika·A V KustD N Voronin

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