Mar 1, 2017

IL-10-Producing CD1d(hi)CD5(+) Regulatory B Cells May Play a Critical Role in Modulating Immune Homeostasis in Silicosis Patients

Frontiers in Immunology
Ying ChenJie Chen

Abstract

Silicosis is characterized by chronic lung inflammation and fibrosis, which are extremely harmful to human health. The pathogenesis of silicosis involves uncontrolled immune processes. Evidence supports that regulatory B cells (Bregs) produce negative regulatory cytokines, such as IL-10, which can negatively regulate immune responses in inflammation and autoimmune diseases. Our previous study found that IL-10-producing B cells were involved in the development of silica-induced lung inflammation and fibrosis of mice. However, little is known about the role of Bregs in silicosis patients (SP). In this study, we found that serum concentrations of IL-10 were significantly increased in SP by using protein array screening. We further determined that the frequency of IL-10-producing CD1d(hi)CD5(+) Bregs, not IL-10-producing non-B lymphocytes, was significantly higher in SP compared to subjects under surveillance (SS) and healthy workers (HW) by flow cytometry. We also found that regulatory T cells (Tregs) and Th2 cytokines (IL-4, IL-5, and IL-13) were significantly increased in SP. Th1 cytokines (IFN-γ, IL-2, and IL-12) and inflammatory cytokines (IL-1β, IL-6, and TNF-α) were not significantly different between SP, SS, and HW. Our stu...Continue Reading

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Mentioned in this Paper

Study
Immune Response
Pathogenic Aspects
Flow Cytometry
CD1D gene
Pathogenesis
Tumor Necrosis Factor-alpha
Il4
Il13
Research Subject

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