IL-10-producing regulatory B cells (B10 cells), IL-17+ T cells and autoantibodies in systemic sclerosis

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Athanasios MavropoulosLazaros I Sakkas

Abstract

We aimed to analyze IL-10+ Breg (B10) cells, found to be reduced in systemic sclerosis (SSc), in relation to SSc-specific autoAbs and IL-17+ and IFNγ+ T cells in SSc. Peripheral blood B10 cells from 26 patients with SSc positive for anti-Topo I or anti-Cen autoAbs, and 12 healthy controls (HC) were studied by flow cytometry. IL-17+ and IFNγ+ T cells were also studied. B10 cells did not correlate with anti-Topo I or anti-Cen Ab levels but were inversely correlated with IL-17+ CD3+ cells and IFNγ+ CD3+ cells. IL-17+ CD3+ cells did not correlate with autoAb levels, but IFN-γ+ CD3+ cells were inversely correlated with anti-Topo I levels. In conclusion, in SSc, B10 cells did not correlate with SSc-specific autoAbs and exhibited an inverse correlation with IL-17+ T cells and IFNγ+ T cells.

Citations

Mar 24, 2018·Cellular & Molecular Immunology·Carlo SelmiM Eric Gershwin
Apr 4, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·Ying GuJianzhong Zhang
Dec 26, 2018·Frontiers in Immunology·Athanasios GkoutzourelasLazaros I Sakkas
Apr 8, 2020·Frontiers in Public Health·Hongli GuanXiaohong Peng
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