IL-10 regulates adult neurogenesis by modulating ERK and STAT3 activity

Frontiers in Cellular Neuroscience
Leticia PereiraEsther Pozas

Abstract

The adult subventricular zone (SVZ) contains Nestin+ progenitors that differentiate mainly into neuroblasts. Our previous data showed that interleukin-10 (IL-10) regulates SVZ adult neurogenesis by up-regulating the expression of pro-neural genes and modulating cell cycle exit. Here we addressed the specific mechanism through which IL-10 carries out its signaling on SVZ progenitors. We found that, in vitro and in vivo, IL-10 targets Nestin+ progenitors and activates the phosphorylation of ERK and STAT3. The action of IL-10 on Nestin+ progenitors is reversed by treatment with a MEK/ERK inhibitor, thus restoring neurogenesis to normal levels. Silencing STAT3 expression by lentiviral vectors also impaired neurogenesis by blocking the effects of IL-10. Our findings unveil ERK and STAT3 as effectors of IL-10 in adult SVZ neurogenesis.

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Citations

Feb 5, 2019·CNS Spectrums·Célia FourrierBernhard T Baune
Oct 16, 2019·The Journal of Experimental Medicine·Margarida SaraivaAnne O'Garra
May 1, 2020·CNS Neuroscience & Therapeutics·Roxana Rodríguez-BarreraAntonio Ibarra
Mar 22, 2019·International Journal of Molecular Medicine·Anna TyrtyshnaiaEkaterina Ermolenko
Mar 8, 2018·Molecular Medicine Reports·Agnese GugliandoloEmanuela Mazzon
Sep 21, 2019·Journal of Cellular Physiology·Naiomy D Rios-ArceNarayanan Parameswaran
Nov 17, 2020·Frontiers in Molecular Neuroscience·Anneke MiedemaSusanne M Kooistra
Nov 26, 2020·International Journal of Molecular Sciences·Morris Losurdo, Mariagrazia Grilli
Jan 21, 2021·CNS Neuroscience & Therapeutics·Huan WangXiangjian Zhang
Jul 3, 2021·Cells·Roxana Rodríguez-BarreraAntonio Ibarra
Aug 5, 2021·Brain, Behavior, & Immunity Health·Hyunah LeeSandrine Thuret
Aug 31, 2021·Cellular and Molecular Neurobiology·Bhakta Prasad Gaire

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