PMID: 8946277Nov 1, 1996Paper

IL-10 suppresses cell surface CD23/Fc epsilon RII expression, not by enhancing soluble CD23 release, but by reducing CD23 mRNA expression in human monocytes

Journal of Clinical Immunology
A MorinobuK Nakao

Abstract

To examine a possible involvement of interleukin-10 (IL-10) in CD23/Fc epsilon RII expression in human monocytes, effects of IL-10 on the cell surface CD23 expression, soluble CD23 (sCD23) release, and CD23 type b mRNA expression were investigated. IL-10 suppressed IL-4-induced surface CD23 expression on monocytes in a dose-dependent manner, and this effect was completely neutralized by anti-IL-10 antibody. The suppressive effect of IL-10 on surface CD23 expression was not due to enhancement of sCD23 release from the cell surface because no increase in sCD23 in culture supernatant was detected after incubation with IL-10. Instead, the effect of IL-10 seemed to be exerted at the transcriptional level since IL-4-induced expression of CD23 type b mRNA was significantly reduced when IL-10 was present. Although IL-4 induced surface CD23 expression on both monocytes and B cells, the suppressive effect of IL-10 was observed only on monocytes, which underscores different regulatory mechanisms for CD23 expression between the two cell types.

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Citations

Apr 3, 2001·AIDS Research and Human Retroviruses·L S MillerH G Durkin
Aug 5, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·R P DonnellyD S Finbloom
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Nov 18, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A C RoeverM Worm
Aug 31, 2001·Genes and Immunity·S Yen ChongE Raveche

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