IL-10 treatment decreases blood pressure in male, but not female, spontaneously hypertensive rats.

American Journal of Physiology. Renal Physiology
Ellen E GillisJennifer C Sullivan

Abstract

Interleukin-10 (IL-10) is an anti-inflammatory cytokine that induces nitric oxide (NO) production. IL-10 supplementation has been previously shown to lower blood pressure (BP) in male hypertensive mice, but the effect of exogenous IL-10 in hypertensive female rodents has not been studied. For the present study, we hypothesized that chronic infusion of IL-10 in hypertensive rats would lower BP concomitant with an increase in renal NO synthase (NOS) activity. Male and female spontaneously hypertensive rats (SHRs; 12 wk old) were randomized to receive IL-10 infusion by subcutaneous minipump (3.5 µg·kg-1·day-1) or serve as sham controls (n = 4-6 rats per treatment per sex). BP was measured by tail cuff before and after 2 wk of treatment. Renal T cells and IL-10 were measured by flow cytometry, and NOS activity was determined by conversion of radiolabeled arginine to radiolabeled citrulline. Female SHRs had greater IL-10+ renal cells than male SHRs and greater expression of the IL-10 receptor at baseline. BP did not change in female SHRs treated with IL-10, but BP significantly decreased following IL-10 infusion in male SHRs. Contrary to our hypothesis, NOS enzymatic activity decreased with IL-10 treatment in the renal inner medulla...Continue Reading

References

Jul 19, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Jennifer C SullivanJennifer S Pollock
May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
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Jul 5, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ashlee J TiptonJennifer C Sullivan
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Dec 17, 2014·American Journal of Physiology. Renal Physiology·Margaret A ZimmermanJennifer C Sullivan
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Sep 22, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Lia E TaylorJennifer C Sullivan

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Citations

Nov 10, 2020·American Journal of Physiology. Renal Physiology·Christine A Klemens, Alexander Staruschenko

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Datasets Mentioned

BETA
EIA33410565

Methods Mentioned

BETA
ELISA
flow cytometry

Software Mentioned

GraphPad Prism

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