IL-11 expression in retinal and corneal cells is regulated by interferon-gamma.

Biochemical and Biophysical Research Communications
Chandrasekharam N NagineniBarbara Detrick

Abstract

Interleukin-11 (IL-11) is an anti-apoptotic, anti-inflammatory cytokine with hematopoietic potential. The expression and protective actions of IL-11 have not been explored in the eye. The expression of IL-11 in primary cultures of human retinal pigment epithelial (HRPE) and human corneal fibroblast (HCRF) cells were evaluated in these studies. Constitutive secretion of IL-11 was not observed in either HRPE or HCRF. TNF-alpha+IL-1 induced IL-11 secretion and this production was inhibited by NFkappaB pathway inhibitors. IFN-gamma significantly inhibited TNF-alpha and IL-1 induced IL-11 secretion and inhibitors of JAK-STAT pathway reversed this inhibition. TGF-beta induced IL-11 secretion that was blocked by TGF-beta receptor 1 inhibitor but not by IFN-gamma. RT-PCR analysis confirmed the effects of IL-1, TNF-alpha, IFN-gamma and TGF-beta on IL-11 secretion at mRNA levels. Our results demonstrate that IL-11 is dramatically up regulated in retina and cornea cells and that IFN-gamma is a physiological inhibitor of IL-11 expression.

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Citations

Jan 19, 2010·Immunologic Research·Barbara Detrick, John J Hooks
Jan 5, 2016·Journal of Biomolecular Structure & Dynamics·Alexei S KazakovSergei E Permyakov
Apr 5, 2013·Veterinary Ophthalmology·Tara R RichardsJonathan LaMarre
Jun 24, 2016·Cell Biochemistry and Biophysics·Eugene A PermyakovSergei E Permyakov
Jun 5, 2019·Growth Factors·Paul M NguyenTracy L Putoczki
Nov 20, 2019·Scientific Reports·Nimisha R KumarArkasubhra Ghosh
Jul 21, 2012·The Ocular Surface·Wanwen LanLouis Tong

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