PMID: 8958917Oct 31, 1996Paper

IL-12-deficient mice are defective but not devoid of type 1 cytokine responses

Annals of the New York Academy of Sciences
J MagramM K Gately

Abstract

Interleukin-12 (IL-12) has been described as a pivotal molecule in the immune response based in part on its ability to influence the differentiation of T helper (Th) cells into a type 1 (Th1) phenotype. This event is crucial in that appropriate differentiation of naive T cells can determine susceptibility or resistance to given pathogens by influencing the balance between cellular and humoral immunity. In order to further delineate the role of IL-12 in the immune response, we generated mice deficient for this cytokine. IL-12 knockout mice were viable, fully fertile, and displayed no obvious developmental abnormalities. Upon immunological analysis, these mice demonstrated an impaired ability to effect a Th1 response as well as an impaired ability to produce interferon-gamma in response to endotoxin in vivo. These data establish an essential role for IL-12 in the generation of optimal Th1 responses in vivo, but weak responses can occur independently of IL-12.

References

Jan 1, 1995·European Journal of Immunology·S GillessenM K Gately
Oct 1, 1994·European Journal of Immunology·M K KennedyK H Grabstein
Jan 16, 1996·Journal of Immunological Methods·V L WilkinsonD H Presky
Sep 1, 1995·Research in Immunology·D H PreskyM K Gately
Apr 25, 2008·Current Protocols in Immunology·M K GatelyD H Presky

❮ Previous
Next ❯

Citations

Oct 11, 2011·Cancer Immunology, Immunotherapy : CII·Fanqi BaiPearlie Epling-Burnette
Feb 10, 2004·Progress in Retinal and Eye Research·Linda Dondero Hazlett
Oct 9, 2003·The Journal of Laboratory and Clinical Medicine·Mark SchuylerAmy Cherne
Aug 15, 2002·Transplantation Proceedings·W WaegellS Banerjee
Nov 30, 2002·Virus Research·Yanira OsorioHomayon Ghiasi
Jun 5, 2003·Burns : Journal of the International Society for Burn Injuries·Hiroyuki KobayashiFujio Suzuki
Jun 25, 1998·Current Opinion in Immunology·K D LiuM A Goldsmith
Mar 17, 2001·Microbes and Infection·C L Karp, M Wills-Karp
Feb 19, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M R StämpfliM Jordana
Jun 22, 1999·The Journal of Experimental Medicine·T OhtekiS Koyasu
Jun 20, 2007·The Journal of Experimental Medicine·Dimitris Skokos, Michel C Nussenzweig
Sep 26, 2008·The Journal of Infectious Diseases·Mark BarkhuizenFrank Brombacher
Feb 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Andrea KrögerPeter P Mueller
Jun 2, 2009·Journal of Molecular Cell Biology·Yisong Y Wan, Richard A Flavell
Oct 15, 2011·Science·Melissa KaneTatyana V Golovkina
Apr 7, 2010·Science Translational Medicine·Omar A AliDavid J Mooney
Dec 26, 2002·Annual Review of Immunology·Susanne J SzaboLaurie H Glimcher
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Irma AiroldiVito Pistoia
Jun 27, 2002·International Journal of Experimental Pathology·Mark SchuylerAmy Cherne
Feb 20, 2007·Journal of Periodontal Research·J AlayanC S Farah
Jul 11, 2008·Immunological Reviews·William P ArendCem Gabay
Jan 15, 2014·JAK-STAT·Aaron F HeneghanKenneth A Kudsk

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.