IL-12 directly stimulates expression of IL-10 by CD5+ B cells and IL-6 by both CD5+ and CD5- B cells: possible involvement in age-associated cytokine dysregulation

International Immunology
N F Spencer, R A Daynes

Abstract

Constitutive expression of p35 and p40 IL-12 mRNA was detected in splenic macrophages isolated from aged mice. Macrophages were also implicated as the cell type responsible for the dysregulated IL-6 and tumor necrosis factor (TNF)-alpha commonly observed to be constitutively produced by lymphoid cells from aged donors. A role for IL-12 in the aging process was suggested when it was found that recombinant IL-12 (rIL-12) directly stimulated splenic CD5+ B cells to secrete IL-10, and both CD5+ and CD5- B cells could be directly induced to produce IL-6 in response to rIL-12. Furthermore, splenocytes from aged animals cultured in the presence of anti-IL-12 antibodies demonstrated a significant reduction in spontaneous IL-6, IL-10 and IFN-gamma production. Based on these observations it was concluded that IL-12 might be responsible for the dysregulated production of IL-10 and IFN-gamma known to occur in aged animals. Treatment of aged animals with low doses of dehydroepiandrosterone sulfate, previously established to be immunocorrective in immunosenescent animals, reduced the age-associated alterations in IL-12 mRNA and protein expression. The mechanisms responsible for the abnormal constitutive expression of inflammatory cytokines b...Continue Reading

Citations

Mar 6, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Steven K Lundy
Apr 29, 1999·Mechanisms of Ageing and Development·S C CastleT Makinodan
Feb 17, 1998·Developmental and Comparative Immunology·D Frasca, G Doria
Mar 17, 2001·Archives of Gerontology and Geriatrics·L MalaguarneraA Messina
Sep 10, 2002·Transplant Immunology·Benjamin A Bradley
Jun 24, 2010·The Proceedings of the Nutrition Society·J RomeoA Marcos
Jan 8, 2013·Cellular & Molecular Immunology·Min YangLiwei Lu
Sep 8, 1999·The Journal of Experimental Medicine·H Wang, M J Shlomchik
Feb 26, 1998·Immunological Reviews·G Doria, D Frasca
Aug 18, 1999·Immunological Reviews·O T ChanM J Shlomchik
Aug 24, 2004·Infection and Immunity·Jan EhrchenCord Sunderkötter
Jul 1, 2004·Arthritis Research & Therapy·Sara A Johnson, John C Cambier
Aug 27, 2009·Arthritis Research & Therapy·Steven K Lundy, David A Fox
Nov 30, 2007·Clinical Interventions in Aging·David S Senchina, Marian L Kohut
May 23, 2014·Nature Reviews. Nephrology·Jessica StolpKathryn J Wood
Jan 25, 2013·Immunity & Ageing : I & a·Sudhir GuptaSastry Gollapudi
Feb 1, 2007·Kidney International·A Reutzel-SelkeS G Tullius
Mar 8, 2016·The Journal of Allergy and Clinical Immunology·Takashi MatsushitaManabu Fujimoto
Sep 2, 2008·Immunological Reviews·Jean-David BouazizThomas F Tedder
Jul 11, 2008·Immunological Reviews·Koichi YanabaThomas F Tedder
Feb 12, 2010·Annals of the New York Academy of Sciences·David J DiLilloThomas F Tedder
Oct 19, 2004·Experimental Gerontology·Marian L KohutJan A Moynihan
May 23, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Zhiwei XuLaurence Morel
Feb 2, 2011·The American Journal of Pathology·Koichi YanabaShinichi Sato
Jul 5, 2011·Medical Hypotheses·A DayakarR Maurya
Dec 19, 2002·International Reviews of Immunology·Matthew L Deschoolmeester, Kathryn J Else
Feb 11, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thomas F Tedder
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A C La FlammeE J Pearce
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Koichi YanabaThomas F Tedder
Jan 1, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mayuka HorikawaThomas F Tedder

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.