IL-13 and TH2 cytokine exposure triggers matrix metalloproteinase 7-mediated Fas ligand cleavage from bronchial epithelial cells

The Journal of Allergy and Clinical Immunology
Samuel J WadsworthDelbert R Dorscheid

Abstract

Bronchial epithelial damage and activation likely contribute to the inflammatory and airway-remodeling events characteristic of severe asthma. Interaction of Fas receptor (CD95) with its ligand (FasL; CD95L) is an important mechanism of cell-mediated apoptosis. Bronchial epithelial FasL expression provides immune barrier protection from immune cell-mediated damage. Membrane FasL (mFasL) is a cleavage target of matrix metalloproteinases (MMPs). We investigated whether the asthmatic T(H)2 environment might influence disease processes by increasing airway epithelial MMP-mediated cleavage of mFasL into proinflammatory soluble FasL. We used human airway epithelial cell lines and primary cells to model the human airway epithelium in vitro. Airway tissue from healthy subjects and patients with severe asthma was used to investigate MMP expression patterns in diseased airways. We demonstrate that active MMP-7 is present in the ciliated epithelial cells of normal human airways. In patients with severe asthma, MMP-7 levels are increased in basal epithelial cells. Airway epithelial cell lines (1HAEo(-) and 16HBE14o(-)) in vitro express constitutively high levels of MMP-2 and MMP-9 but relatively low levels of MMP-7. T(H)2 cytokine (IL-4, I...Continue Reading

References

Jan 30, 1992·The New England Journal of Medicine·D S RobinsonA B Kay
Jan 1, 1991·Advances in Experimental Medicine and Biology·A L CozensD C Gruenert
Mar 1, 1989·The American Review of Respiratory Disease·R BeasleyS T Holgate
Apr 1, 1985·The American Review of Respiratory Disease·L A LaitinenT Haahtela
Jan 1, 1983·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·K P KeenanE M McDowell
Jan 1, 1994·American Journal of Respiratory Cell and Molecular Biology·A L CozensD C Gruenert
Aug 1, 1993·The American Review of Respiratory Disease·D L Smith, R D Deshazo
Mar 1, 1996·Nature Medicine·M TanakaS Nagata
Jan 1, 1997·American Journal of Respiratory Cell and Molecular Biology·P M LackieS T Holgate
Feb 26, 1998·American Journal of Respiratory and Critical Care Medicine·A M VignolaJ Bousquet
Oct 8, 1998·American Journal of Respiratory Cell and Molecular Biology·K J HamannS R White
Oct 14, 1998·The Journal of Clinical Investigation·S E DunsmoreW C Parks
Nov 7, 1998·American Journal of Respiratory Cell and Molecular Biology·A DruilheM Pretolani
Jul 27, 1999·The Histochemical Journal·D R DorscheidS R White
Apr 14, 2000·American Journal of Respiratory and Critical Care Medicine·C L OrdoñezJ V Fahy
Jun 28, 2000·Lung·P R BhathenaS C Erzurum
Jul 6, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S M PuddicombeD E Davies
Aug 31, 2001·The Journal of Biological Chemistry·Y S López-BoadoW C Parks
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·D R DorscheidS R White
Jan 17, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Henry DanahayChristopher T Poll
Dec 5, 2002·Archives of Biochemistry and Biophysics·Tracy Vargo-GogolaLynn M Matrisian
Apr 25, 2003·International Journal of Pharmaceutics·Ben ForbesAlison B Lansley
May 22, 2003·The American Journal of Pathology·John K McGuireWilliam C Parks
Jul 10, 2003·Chemical Immunology·S T Holgate
Nov 19, 2003·Molecular and Cellular Biochemistry·Sajal ChakrabortiTapati Chakraborti
Jul 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·John F GrehanAgustin P Dalmasso
Sep 16, 2006·Immunological Reviews·Thomas A Ferguson, Thomas S Griffith
May 22, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Benjamin J PatchellDelbert R Dorscheid
Oct 4, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mei-Lun WangGary D Wu

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Citations

Jun 3, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ana Paula Moreira, Cory M Hogaboam
Dec 29, 2011·Journal of Allergy·Steven R White
Jan 25, 2011·American Journal of Respiratory Cell and Molecular Biology·Alex W FarnandGustavo Matute-Bello
Jul 28, 2011·Journal of Asthma and Allergy·Sj WadsworthDr Dorscheid
Aug 29, 2014·DNA and Cell Biology·Nam E JooYvonne L Kapila
Jun 15, 2013·Paediatric Respiratory Reviews·Henry J Rozycki, Wei Zhao
Apr 26, 2012·Pulmonary Pharmacology & Therapeutics·Khanh vinh quoc Luong, Lan Thi Hoàng Nguyen
Apr 21, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A H PoonQ Hamid
Aug 10, 2015·Cytokine·Richard D May, Michael Fung
May 28, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·S L FieldN M Orsi
Mar 8, 2011·The Journal of Allergy and Clinical Immunology·David H BroideMarc E Rothenberg
Aug 25, 2016·The Journal of Allergy and Clinical Immunology·Katharina DietzJulia Esser-von Bieren
Jan 19, 2017·Journal of Clinical Medicine·Qiuchen GuoPepper Schedin
Mar 5, 2011·Therapeutic Advances in Respiratory Disease·Anthony TamDon D Sin
Dec 3, 2016·Clinical Microbiology Reviews·Cameron GriffithsDavid J Marchant
Nov 30, 2018·Annual Review of Physiology·Maor SaulerPatty J Lee
Mar 27, 2019·Multidisciplinary Respiratory Medicine·Martina SterclovaMartina Vasakova
Jul 8, 2020·Biomolecules·Zhao LiuYouhua Liu
Mar 7, 2021·International Journal of Molecular Sciences·Shulamit B Wallach-DayanRaphael Breuer
May 8, 2021·Journal of Cellular and Molecular Medicine·Jiapeng HuYunxiao Shang

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