IL-15 superagonist RLI has potent immunostimulatory properties on NK cells: implications for antimetastatic treatment.

Journal for Immunotherapy of Cancer
Mélanie DesboisNathalie Chaput

Abstract

As the immune system is compromised in patients with cancer, therapeutic strategies to stimulate immunity appear promising, to avoid relapse and increase long-term overall survival. Interleukin-15 (IL-15) has similar properties to IL-2, but does not cause activation-induced cell death nor activation and proliferation of regulatory T cells (Treg), which makes it a serious candidate for anticancer immunotherapy. However, IL-15 has a short half-life and high doses are needed to achieve responses. Designed to enhance its activity, receptor-linker-IL-15 (RLI) (SO-C101) is a fusion molecule of human IL-15 covalently linked to the human IL-15Rα sushi+ domain currently assessed in a phase I/Ib clinical trial on patients with advanced/metastatic solid cancer. We investigated the antimetastatic activity of RLI in a 4T1 mouse mammary carcinoma that spontaneously metastasizes and evaluated its immunomodulatory role in the metastatic lung microenvironment. We further characterized the proliferation, maturation and cytotoxic functions of natural killer (NK) cells in tumor-free mice treated with RLI. Finally, we explored the effect of RLI on human NK cells from healthy donors and patients with non-small cell lung cancer (NSCLC). RLI treatment...Continue Reading

References

Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·V GrohT Spies
Mar 8, 2000·The Journal of Experimental Medicine·M K KennedyJ J Peschon
Oct 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·J Marks-KonczalikY Tagaya
Oct 17, 2001·The Journal of Experimental Medicine·J P LodolceA Ma
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Scott H RobbinsLaurent Brossay
Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Scott H RobbinsLaurent Brossay
Mar 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giovanni C CesanaHoward L Kaufman
Jun 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Mark P RubinsteinJonathan Sprent
Jul 4, 2006·Cytokine & Growth Factor Reviews·Vadim BudagianSilvia Bulfone-Paus
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thomas A StoklasekLeo Lefrançois
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carl G FengAlan Sher
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sigrid DuboisJürgen R Müller
Mar 28, 2008·Immunological Reviews·Martin A Cheever
Dec 24, 2008·The Journal of Experimental Medicine·Nicholas D HuntingtonJames P Di Santo
Jan 13, 2009·Nature·Joseph C SunLewis L Lanier
Feb 7, 2009·Journal of Proteome Research·Marie-Lyn HechtPeter H Seeberger
Jul 17, 2009·Blood·Carolina BergerStanley R Riddell
Nov 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·Kutlu G ElpekShannon J Turley
Mar 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Nicholas D HuntingtonJames P Di Santo
May 10, 2011·Nature Medicine·Nicolas F DelahayeLaurence Zitvogel
Aug 16, 2011·The Journal of Clinical Investigation·Emilie MamessierDaniel Olive
Jan 29, 2013·International Journal of Cancer. Journal International Du Cancer·Marie VincentYannick Jacques
May 10, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leslie A FogelAnthony R French
Nov 10, 2013·Nature Medicine·Daniela F Quail, Johanna A Joyce
Jan 28, 2015·Proceedings of the National Academy of Sciences of the United States of America·Amy-Jo CasbonZena Werb
May 25, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mélanie DesboisNathalie Chaput
Jan 17, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M CharrierN Chaput
Mar 23, 2019·Journal for Immunotherapy of Cancer·Karin M KnudsonSofia R Gameiro
Sep 25, 2019·International Journal of Molecular Sciences·Marie Frutoso, Erwan Mortier

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Citations

Nov 19, 2020·Journal for Immunotherapy of Cancer·Piera Filomena FioreBruno Azzarone
Mar 7, 2021·Cancers·Cristina BergamaschiGeorge N Pavlakis
Apr 6, 2021·Frontiers in Immunology·Xiang Wang, Xiang-Yu Zhao
Aug 28, 2021·International Journal of Molecular Sciences·Nicolas JacquelotPamela S Ohashi

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Methods Mentioned

BETA
flow cytometry
FACS
Feature Extraction

Software Mentioned

R bioconductor package
Kaluza
GraphPad
gMedianSignal
Prism
ArrayQualityMetrics
R
Agilent Feature Extraction
R script
R bioconductor

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