IL-17 and colorectal cancer risk in the Middle East: gene polymorphisms and expression

Cancer Management and Research
Omar A Al ObeedMaha-Hamadien Abdulla

Abstract

IL-17 expressed by Th17 cells play a crucial role in tissue inflammation by induction of proinflammatory and neutrophil mobilizing cytokines, and IL-17 polymorphisms are associated with colorectal cancer (CRC). We investigated the expression of IL-17 and the association of IL-17 gene polymorphisms with CRC susceptibility in a Middle East population. The study included 117 diagnosed CRC patients and 100 age- and gender-matched healthy controls. IL-17A rs2275913 (G197A) and IL-17F rs763780 (T7488C) single nucleotide polymorphisms, mRNA, and protein levels of IL-17A were assessed. We observed significant association between rs2275913 in IL-17A and susceptibility to CRC (p = 0.016228). The AG and AA genotypes conferred 2-fold and 2.8-fold, respectively, higher risk of developing CRC compared with individuals having GG genotype. Stratification of the data based on gender and age revealed very strong association of CRC with IL17A rs2275913 only in males and "AG" genotype in patients ≤57 years of age at the time of disease diagnosis. The rs763780 in IL-17F was not linked with CRCs in our cohort. Furthermore, IL-17A mRNA expression in CRCs was significantly elevated compared to adjacent normal tissues, particularly in early stages of d...Continue Reading

Citations

Nov 16, 2019·The Journal of Experimental Medicine·Junjie ZhaoXiaoxia Li
May 28, 2019·Frontiers in Immunology·Alessandro PoggiMaria Raffaella Zocchi
Dec 17, 2020·The Journal of International Medical Research·Shulong Zhang, Xiaoting Wang

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BETA
PCR
genotyping

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GraphPad Prism

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