IL-17 and IFN-gamma mRNA expression is increased in the brain and systemically after permanent middle cerebral artery occlusion in the rat

Journal of Neuroimmunology
H L LiH Link

Abstract

Brain ischemia is characterized by local inflammation reflected by accumulation of inflammatory cells and a multitude of mediators. Among them, cytokines and chemokines may influence the inflammatory cascade that follows cerebral ischemia. Here we report on brain hemispheric and systemic increase of pro-inflammatory IL-17 and IFN-gamma, the anti-inflammatory cytokines IL-4 and IL-10, and the chemokines IP-10, IL-8 and MIP-2, 1 h to 6 days after permanent middle cerebral artery occlusion (pMCAO). IL-17 and IFN-gamma mRNA levels were elevated in the ischemic hemispheres of pMCAO-operated rats compared with corresponding hemispheres of sham-operated rats. Levels were slightly elevated at 1 h, and peaked at 6 days after pMCAO. IL-8 and MIP-2 levels in the ischemic hemispheres peaked at 24 h, whereas IP-10 showed a biphasic profile with two peaks at 6 h and 6 days after pMCAO. IL-4 peaked in the ischemic hemispheres at 6 h, when IL-10 levels were lower than in sham-operated rats, and IL-10 levels peaked at 2 days after pMCAO. Systemically, the numbers of IL-17 and IFN-gamma mRNA expressing blood mononuclear cells were elevated already at 1 h after pMCAO, preceding the changes in the ischemic hemispheres. Altered levels of IL-17 and ...Continue Reading

References

Feb 1, 1991·Journal of Neuroscience Research·W F HickeyH Kimura
Jun 1, 1986·The Journal of General Virology·P H van der MeideH Schellekens
Dec 1, 1989·The Journal of Experimental Medicine·D F FiorentinoT R Mosmann
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S D WolpeA Cerami
Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·E Z LongaR Cummins
Jul 1, 1994·Stroke; a Journal of Cerebral Circulation·T LiuG Z Feuerstein
May 1, 1993·Trends in Pharmacological Sciences·F Powrie, R L Coffman
Nov 1, 1993·Stroke; a Journal of Cerebral Circulation·T LiuG Z Feurestein
Sep 3, 1998·Neuroscience Letters·P A SperaF C Barone
Sep 8, 1998·Neuroimmunomodulation·G Z FeuersteinF C Barone
Oct 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T J SickM Rosenthal
Nov 27, 1998·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·N MukaidaK Matsushima

❮ Previous
Next ❯

Citations

Feb 23, 2012·Metabolic Brain Disease·Hilary A SeifertKeith R Pennypacker
Jul 7, 2009·Neuromolecular Medicine·Gokhan Yilmaz, D Neil Granger
May 17, 2005·Journal of the Neurological Sciences·Dan FrenkelHoward L Weiner
May 14, 2003·Brain Research·Celine A WishcamperDiana I Lurie
Mar 26, 2003·Cytokine & Growth Factor Reviews·T A MoseleyA H Reddi
Oct 1, 2009·Stem Cells and Development·Lixian JiangAlison E Willing
Nov 14, 2007·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Hong-xing ZhangMin Yang
Apr 20, 2014·Journal of Neuroinflammation·Yao ZhangGuangyou Wang
Jun 5, 2014·Translational Stroke Research·Hilary A Seifert, Keith R Pennypacker
Apr 15, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Tatsuro NishiPak H Chan
Jul 10, 2004·Acta Neurologica Scandinavica·K Wada-IsoeK Nakashima
Feb 27, 2015·Acta Neuropathologica·Ari WaismanTommy Regen
Sep 23, 2016·Journal of Neuroinflammation·Deidre JanssonMike Dragunow
Nov 9, 2016·Frontiers in Immunology·Gillipsie MinhasNooruddin Khan
Nov 11, 2016·Journal of Neuroinflammation·Juan Carlos Pena-PhilippidesTamara Roitbak
Dec 20, 2014·Scientific Reports·Qiang LiuJie Wu
Aug 12, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Denis ArsenijevicPanteleimon Giannakopoulos
Mar 5, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Michaela C PascoeDavid P Crewther
Sep 25, 2008·International Journal of Stroke : Official Journal of the International Stroke Society·P A McCombe, S J Read
Sep 12, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Isabel Pérez-de PuigAnna M Planas
Jan 6, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yang TangFrank R Sharp
Dec 7, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hedley C A Emsley, Pippa J Tyrrell
Nov 20, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yasushi TakagiMichael A Moskowitz
Jan 5, 2018·Stem Cells and Development·Guilong ZhangYongbo Yu
Apr 26, 2006·Circulation·Gokhan YilmazD Neil Granger
Apr 6, 2002·Stroke; a Journal of Cerebral Circulation·Nikolaos KostulasHans Link
Feb 27, 2010·Annals of Neurology·Thiruma V ArumugamRuiqian Wan
Jun 26, 2020·Frontiers in Immunology·Jelena MilovanovicNebojsa Arsenijevic
Aug 9, 2018·Frontiers in Cellular Neuroscience·Starlee Lively, Lyanne C Schlichter
Mar 13, 2018·Frontiers in Molecular Neuroscience·Tamara Roitbak
Sep 30, 2004·Journal of Neuropathology and Experimental Neurology·Kate Lykke LambertsenBente Finsen
Dec 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dan FrenkelHoward L Weiner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

© 2021 Meta ULC. All rights reserved