IL-17 and IL-17F modulate GM-CSF production by lung microvascular endothelial cells stimulated with IL-1beta and/or TNF-alpha

Immunology Letters
Muneo NumasakiHidetada Sasaki

Abstract

In this study, we investigated the roles of CD4 T cell cytokines IL-17 and IL-17F in GM-CSF production from lung microvascular endothelial cells (LMVECs). While a wide range of doses of IL-17 or IL-17F alone did not induce GM-CSF release from LMVECs, IL-17 had an enhancing effect on macrophage-derived IL-1beta- and TNF-alpha-induced GM-CSF mRNA expression and production, whereas IL-17F had an enhancing effect on IL-1beta-induced GM-CSF production, but a marked inhibitory effect on TNF-alpha-induced secretion. GM-CSF production was further enhanced with the combination of three cytokines IL-1beta, TNF-alpha and IL-17 or IL-17F. Additionally, when Th1 or Th2 cytokine was combined with IL-1beta or TNF-alpha, both Th1 and Th2 cytokines had a modest stimulatory effect on TNF-alpha-induced GM-CSF production, whereas IL-4 and IFN-gamma profoundly attenuated IL-1beta-induced secretion. Moreover, the regulation by IL-17 plus Th1 or Th2 cytokine of GM-CSF production from LMVECs treated with IL-1beta or TNF-alpha was dependent on the concentration of IL-17. Our findings indicate that IL-17 and IL-17F play a differential regulatory role in GM-CSF production by LMVECs stimulated with IL-1beta and/or TNF-alpha, which is sensitive to Th1 and ...Continue Reading

References

Aug 1, 1993·Thorax·D S RobinsonA B Kay
Jun 1, 1996·The Journal of Experimental Medicine·F FossiezS Lebecque
Sep 22, 1998·The Journal of Experimental Medicine·O V VolpertN P Bouck
Jun 15, 2000·The European Respiratory Journal·A LindénM Laan
Jul 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jürgen BurgCharles James Kirkpatrick
Nov 2, 2002·Blood·Muneo NumasakiMichael T Lotze
Feb 8, 2003·American Journal of Respiratory and Critical Care Medicine·Stefania La GruttaAntonio Maurizio Vignola

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Citations

Jan 1, 2013·Journal of Clinical Immunology·Amita JainRashmi Kumar
Jan 24, 2009·Immunological Reviews·Yoichiro IwakuraHarumichi Ishigame
Mar 15, 2006·American Journal of Reproductive Immunology : AJRI·Sutatip PongcharoenPuntharee Butkhamchot
Jun 5, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shahina Wiehler, David Proud
Dec 29, 2015·Molecular Medicine Reports·Lei WeiJianhua Zhao
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Muneo NumasakiHidetada Sasaki

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