IL-17 and IL-22 production in HIV+ individuals with latent and active tuberculosis

BMC Infectious Diseases
Kamakshi P DevalrajuVijaya Lakshmi Valluri

Abstract

IL-17 and IL-22 cytokines play an important role in protective immune responses against Mycobacterium tuberculosis (Mtb) infection. Information on the production of these cytokines and the factors that regulate their production in the context of human immunodeficiency virus (HIV) and latent tuberculosis infection (LTBI) or active tuberculosis disease (ATB) is limited. In the current study, we compared the production of these two cytokines by PBMC of HIV-LTBI+ and HIV + LTBI+ individuals in response to Mtb antigens CFP-10 (culture filtrate protein) and ESAT-6 (Early Secretory Antigenic Target). We also determined the mechanisms involved in their production. We cultured Peripheral Blood Mononuclear Cells (PBMCs) from HIV- individuals and HIV+ patients with latent tuberculosis and active disease with CFP-10 and ESAT-6. Production of IL-17, IL-22 and PD1 (Programmed Death 1), ICOS (Inducible T-cell Costimulator), IL-23R and FoxP3 (Forkhead box P3) expression on CD4+ T cells was measured. In response to Mtb antigens CFP-10 and ESAT-6, freshly isolated PBMCs from HIV+ LTBI+ and HIV+ active TB patients produced less IL-17 and IL-22 and more IL-10, expressed less IL-23R, and more PD1 and expanded to more FoxP3+ cells. Active TB infecti...Continue Reading

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Citations

Dec 30, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susmita K SinghRobert Blomgran
Apr 3, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Kamakshi Prudhula DevalrajuVijaya Lakshmi Valluri
May 7, 2020·Frontiers in Cellular and Infection Microbiology·Matthew B HuanteJanice J Endsley
Jun 17, 2021·Journal of Cellular Physiology·Utkarsha SahuPrashant Khare

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Methods Mentioned

BETA
flow-cytometry
ELISA
flow cytometry

Software Mentioned

MultiSET
SPSS
MPM
Multivariate Analysis of Variance ( MANOVA )
Graph pad prism

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