IL-17 inhibition: is it the long-awaited savior for alopecia areata?

Archives of Dermatological Research
Yuval RamotFabio Rinaldi

Abstract

Interleukin-17 (IL-17) has been implicated in the pathogenesis of a large number of inflammatory and autoimmune conditions, including skin disorders such as psoriasis. Recently, much data have accumulated on the possible role of IL-17 in the pathogenesis of alopecia areata (AA). In this review, the available information on the connection between AA and IL-17 is described. While IL-17 levels are consistently reported to be elevated in the serum and lesional skin of AA patients, there is no clear connection between IL-17 levels and disease severity or duration. Some evidence has suggested an association between IL-17 and an early-onset disease, although this awaits further confirmation. While there is enough information to support clinical trials with IL-17-targeted treatments, it is possible that they will be effective only in a subset of AA patients. Further studies are warranted to better delineate the exact role of IL-17 in AA pathogenesis.

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Citations

Nov 16, 2018·The Journal of Dermatological Treatment·Piotr CiechanowiczLidia Rudnicka
Aug 20, 2018·Archives of Dermatological Research·Emma Guttman-YasskyMark G Lebwohl
Apr 12, 2019·Biomolecules & Therapeutics·Nahyun Choi, Jong-Hyuk Sung
Nov 12, 2020·Dermatologic Therapy·Layal AntouryKyle Cheng
Apr 21, 2021·Journal of Cosmetic Dermatology·Yıldız HayranBaşak Yalçın
May 18, 2019·Case Reports in Dermatology·Makiko YajimaKeiichi Yamanaka
Jun 1, 2021·Case Reports in Dermatology·Ena MasukawaKeiichi Yamanaka

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