IL-17 primes airway epithelial cells lacking functional Cystic Fibrosis Transmembrane conductance Regulator (CFTR) to increase NOD1 responses

Biochemical and Biophysical Research Communications
Lucie Roussel, Simon Rousseau

Abstract

In Cystic Fibrosis (CF), the absence of functional Cystic Fibrosis Transmembrane conductance Regulator (CFTR) translates into chronic bacterial infection, excessive inflammation, tissue damage, impaired lung function and eventual death. Understanding the mechanisms underlying this vicious circle of inflammation is key to better therapies for CF. In this manuscript, we have found that the presence of IL-17 in the airways of CF patients not only exacerbates inflammation through the recruitment of neutrophils via secretion of CXCL8, but also by priming airway epithelial cells lacking functional CFTR to increase response to the bacterial sensor NOD1. IL-17 stimulation of airway epithelial cells (AECs) lacking functional CFTR increased the expression of NOD1, NOD2, TLR4 and its own receptors IL-17RA and IL-17RC. Moreover, prior stimulation of AECs expressing the CFTRDeltaF508 mutant with IL-17 showed much greater CXCL8 secretion in response to a NOD1 agonist and Pseudomonas aeruginosa diffusible material. Taken together our results show that IL-17 primes AECs expressing CFTRDeltaF508 to increase host defence response to bacteria through the up-regulation of PRRs, and in particular of NOD1, and identifies another mechanism of action ...Continue Reading

References

Feb 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·D KubeP B Davis
Apr 5, 2002·Clinical Microbiology Reviews·Jeffrey B LyczakGerald B Pier
May 16, 2002·Chest·Jadwiga A Wedzicha
Oct 16, 2004·Immunity·Jay K Kolls, Anders Lindén
Apr 5, 2005·Respiratory Research·Qi WuScott H Randell
Dec 14, 2005·Current Opinion in Immunology·Luke A J O'Neill
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Muhammad Shahidur RahmanAbdelilah Soussi Gounni
Nov 18, 2006·Nature Immunology·Jörg H FritzStephen E Girardin
Nov 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Spencer C LiangLynette A Fouser
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chuanwang SongZuo-Hua Feng
Oct 15, 2009·Science Signaling·Caini LiuXiaoxia Li

❮ Previous
Next ❯

Citations

Aug 30, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Haouaria BalghiJohn W Hanrahan
Apr 9, 2011·American Journal of Respiratory and Critical Care Medicine·Hui-Leng TanJane C Davies
Jan 12, 2013·American Journal of Respiratory and Critical Care Medicine·Rossana G IannittiLuigina Romani
Apr 16, 2011·American Journal of Respiratory Cell and Molecular Biology·Stephanie RobinsSimon Rousseau
Sep 4, 2015·Pediatric Pulmonology·David P Nichols, James F Chmiel
Nov 13, 2019·Pediatric Pulmonology·Lucy Perrem, Felix Ratjen
Jun 1, 2018·Mediators of Inflammation·Virginia De RoseCatherine M Greene
Sep 2, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stephen J Gurczynski, Bethany B Moore
Oct 1, 2010·Current Opinion in Pulmonary Medicine

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.