IL-17-Producing Cells in Tumor Immunity: Friends or Foes?

Immune Network
Da-Sol KuenYeonseok Chung

Abstract

IL-17 is produced by RAR-related orphan receptor gamma t (RORγt)-expressing cells including Th17 cells, subsets of γδT cells and innate lymphoid cells (ILCs). The biological significance of IL-17-producing cells is well-studied in contexts of inflammation, autoimmunity and host defense against infection. While most of available studies in tumor immunity mainly focused on the role of T-bet-expressing cells, including cytotoxic CD8+ T cells and NK cells, and their exhaustion status, the role of IL-17-producing cells remains poorly understood. While IL-17-producing T-cells were shown to be anti-tumorigenic in adoptive T-cell therapy settings, mice deficient in type 17 genes suggest a protumorigenic potential of IL-17-producing cells. This review discusses the features of IL-17-producing cells, of both lymphocytic and myeloid origins, as well as their suggested pro- and/or anti-tumorigenic functions in an organ-dependent context. Potential therapeutic approaches targeting these cells in the tumor microenvironment will also be discussed.

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Citations

Jun 12, 2020·Cell Communication and Signaling : CCS·Zhujiang DaiDaorong Wang
Oct 22, 2020·International Journal of Molecular Sciences·Erna Marija MeškytėYari Ciribilli
Nov 28, 2020·Cancer Immunology, Immunotherapy : CII·Qingsheng LiNejat K Egilmez
Jan 23, 2021·Cancers·Matthew R LordoBethany L Mundy-Bosse
Feb 13, 2021·Nature Immunology·Jang Hyun ParkHeung Kyu Lee
May 12, 2021·Molecules and Cells·Jaeho Kim, Heung Kyu Lee
Aug 12, 2021·JHEP Reports : Innovation in Hepatology·Katie HealyMargaret Sällberg Chen
Sep 9, 2021·Cancer Medicine·Neelam MukherjeeRobert S Svatek

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Methods Mentioned

BETA
xenograft

Clinical Trials Mentioned

NCT03396497

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