IL-17 Promotes Scar Formation by Inducing Macrophage Infiltration

The American Journal of Pathology
Julei ZhangDahai Hu

Abstract

Trauma or burn injuries that affect the deep dermis often produce a hypertrophic scar, which limits patients' joint movement and generates an aesthetic problem. Inflammation is believed to be one of the main pathogenic mechanisms. We found that IL-17 was increased in scar tissues from patients with hypertrophic scar compared with normal skin. Recombinant mouse IL-17 was subcutaneously injected into mice that underwent full-thickness excision surgery to investigate the role of IL-17 in scar formation. Mice stimulated with IL-17 showed aggravated fibrogenesis, delayed wound healing, and increased inflammation. In addition, macrophage infiltration was also increased. According to the results of the Transwell assay, IL-17 promoted macrophage infiltration through an indirect mechanism. After depleting macrophages with clodronate liposomes, the effect of IL-17 disappeared. Levels of monocyte chemotactic protein (MCP) 1, MCP2, and MCP3 (together referred to as MCPs) were increased by IL-17 stimulation. Bindarit (an inhibitor of MCPs) was used to verify the role of MCPs. In addition, the Ly6C-low macrophages were responsible for wound fibrogenesis in mice. In this study, we detected the increased levels of IL-17 for the first time and ...Continue Reading

References

Jan 10, 2009·Annual Review of Immunology·Thomas KornVijay K Kuchroo
Feb 24, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tina LucasSabine A Eming
Feb 24, 2010·The Journal of Experimental Medicine·Mark S WilsonThomas A Wynn
Mar 1, 2011·Burns : Journal of the International Society for Burn Injuries·Jennifer R SasakiMartin G Schwacha
Dec 14, 2011·Nature Medicine·Victor W WongGeoffrey C Gurtner
Jul 27, 2012·Arthritis and Rheumatism·Yoshinobu OkamotoKazuhiko Takehara
Oct 2, 2012·Nature Reviews. Drug Discovery·Pierre Miossec, Jay K Kolls
Oct 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Prakash RamachandranJohn P Iredale
May 20, 2014·The Journal of Clinical Investigation·Saeid Amini-NikBenjamin A Alman
Feb 11, 2015·European Journal of Pharmacology·Hui WangYue-Ling Tang
May 6, 2015·Experimental Dermatology·Lenie J van den BroekFrank B Niessen
May 28, 2015·Journal of the American Society of Nephrology : JASN·Meghan ClementsAnna Zuk
Jun 30, 2015·The American Journal of Pathology·Amitava DasSashwati Roy
Jul 27, 2015·Cellular and Molecular Life Sciences : CMLS·Antonio SicaChiara Porta
Jul 29, 2015·Seminars in Immunology·Madhur P Motwani, Derek W Gilroy
Oct 22, 2015·Advances in Wound Care·Lisa BlockTimothy W King
Nov 13, 2015·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Li-Wu QianKai P Leung
Mar 31, 2016·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Ryan S ChiangAlan D Widgerow
May 14, 2016·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Zhensen ZhuEdward E Tredget
Jun 2, 2016·Experimental Dermatology·Liselotte ButzelaarFrank B Niessen
Aug 12, 2016·Experimental Dermatology·Sun Hyung Kwon, Geoffrey C Gurtner

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Citations

Oct 4, 2019·The Journal of Pathology·Yi-Ting ChenShuei-Liong Lin
Dec 12, 2019·Tissue Engineering and Regenerative Medicine·Hui Song CuiJune-Bum Kim
Aug 30, 2020·Inflammation·Lucas Buzeli de SouzaThiago Antônio Moretti de Andrade
Dec 13, 2019·Mediators of Inflammation·Yasmin HadianR Rivkah Isseroff
May 11, 2019·Rheumatology International·Sakir AhmedVikas Agarwal
Feb 23, 2020·International Journal of Molecular Sciences·Makoto Sugaya
Jun 13, 2020·Stem Cell Research & Therapy·Tong XiaoYumin Xia
Oct 10, 2020·Scientific Reports·Chen-Hsueh PaiShu-Wha Lin
Jan 5, 2021·Current Opinion in Nephrology and Hypertension·David P BasileDavid L Mattson
Dec 22, 2020·Frontiers in Immunology·Zheng-Cai WangWei-Qiang Tan
Apr 2, 2021·Kidney Research and Clinical Practice·David P BasilePurvi Mehrotra
Jul 18, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Menglei WangLi Li
Aug 7, 2021·Frontiers in Cell and Developmental Biology·Ming-Li ZouFeng-Lai Yuan

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