IL-17A and IL-17F induce autophagy in RAW 264.7 macrophages

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
László OroszKlára Megyeri

Abstract

Autophagy is an important cellular catabolic process for the lysosomal degradation of cytoplasmic organelles, proteins and microorganisms. The autophagic process is intertwined with the immune response: autophagy regulates both innate and adaptive immunity, conversely, cytokines produced during the course of the immune response modulate various functions of the autophagic cascade. The IL-17 family member cytokines play a pivotal role in immune protection against extra- and intracellular bacterial pathogens. Since the effects of IL-17A and IL-17F on autophagy have not yet been reported, we have evaluated the autophagic activity in the RAW 264.7 cell line treated with either IL-17A or IL-17F. Both IL-17A and IL-17F proved to promote microtubule-associated protein 1 light chain 3 B-II (LC3B-II) accumulation, enhance the autophagic flux, facilitate the intracellular redistribution of LC3B, increase both the average number and the size of autophagosomes per cell, and foster the formation of acidic vesicular organelles. IL-17F was considerably more efficient than IL-17A in promoting the autophagic process. Further experiments to determine the potential effect of IL-17-induced autophagy on the antibacterial activity of RAW macrophages...Continue Reading

References

Mar 18, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D S SmithJ L Cook
Jan 17, 2007·Autophagy·Daniel J KlionskyPer O Seglen
Dec 26, 2009·Current Opinion in Cell Biology·Zhifen Yang, Daniel J Klionsky
Feb 26, 2011·Immunity·Yoichiro IwakuraSusumu Nakae
Sep 6, 2011·Cytokine·James Harris
Aug 30, 2012·Nature Methods·Caroline A SchneiderKevin W Eliceiri
Sep 12, 2012·Autophagy·Daniel J KlionskyBrian Zuckerbraun
Oct 25, 2012·Proceedings of the National Academy of Sciences of the United States of America·Eliseo F CastilloVojo Deretic
Apr 6, 2013·Cytokine·Xinyang Song, Youcun Qian
Apr 12, 2013·Frontiers in Immunology·James Harris
Apr 27, 2013·Pathogens and Disease·Eun-Kyeong Jo
Jun 25, 2013·Current Opinion in Microbiology·Steven B BradfuteVojo Deretic
Sep 3, 2013·Immunology·Daniel J Puleston, Anna Katharina Simon
Sep 10, 2013·Cytokine·Chunfang GuXiaoxia Li

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