IL-17A-Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Jarod A ZeppXiaoxia Li

Abstract

This study identifies a novel mechanism linking IL-17A with colon tissue repair and tumor development. Abrogation of IL-17A signaling in mice attenuated tissue repair of dextran sulfate sodium (DSS)-induced damage in colon epithelium and markedly reduced tumor development in an azoxymethane/DSS model of colitis-associated cancer. A novel IL-17A target gene, PLET1 (a progenitor cell marker involved in wound healing), was highly induced in DSS-treated colon tissues and tumors in an IL-17RC-dependent manner. PLET1 expression was induced in LGR5+ colon epithelial cells after DSS treatment. LGR5+PLET1+ marks a highly proliferative cell population with enhanced expression of IL-17A target genes. PLET1 deficiency impaired tissue repair of DSS-induced damage in colon epithelium and reduced tumor formation in an azoxymethane/DSS model of colitis-associated cancer. Our results suggest that IL-17A-induced PLET1 expression contributes to tissue repair and colon tumorigenesis.

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Citations

Nov 16, 2019·The Journal of Experimental Medicine·Immo PrinzUlrich Mrowietz
Nov 16, 2019·The Journal of Experimental Medicine·Junjie ZhaoXiaoxia Li
Dec 4, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Travis WalrathWilliam O'Connor
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Dec 8, 2020·Frontiers in Immunology·Taoming LiuHong Fang
Dec 19, 2020·Osteoarthritis and Cartilage·Jingcheng WangYueming Song
Apr 7, 2021·The Journal of Experimental Medicine·Rami BecharaSarah L Gaffen
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Aug 3, 2021·Frontiers in Immunology·Mélanie DieudéMarie-Josée Hébert
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Dec 7, 2021·Frontiers in Immunology·Margaux VienneYann M Kerdiles

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