Abstract
Interleukin-17A(IL-17A), a proinflammatory cytokine, may have effects on osteoclastic resorption in inflammation-mediated bone loss, including postmenopausal osteoporosis. IL-17A could alter autophagic activity among other tissues and cells, thereby causing corresponding lesions. The aim of this study was to clarify how IL-17A influenced osteoclastogenesis by regulating autophagy. The present study showed that IL-17A could facilitate osteoclast precursors (OCPs) autophagy and osteoclastogenesis at a low concentration. Furthermore, suppression of autophagy with chloroquine (CQ) or 3-MA could significantly attenuate the enhanced osteoclastogenesis by a low level of IL-17A. It was also found that a low level of IL-17A couldn't up-regulate OCPs autophagy after removal of RANKL(Receptor Activator for Nuclear Factor-κB Ligand), and JNK(c-Jun N-terminal kinase) inhibitor only inhibited autophagy at a low level of IL-17A. These results suggest that a low concentration of IL-17A is likely to promote autophagic activity via activating RANKL-JNK pathway during osteoclastogenesis.
Citations
Oct 3, 2018·International Journal of Molecular Sciences·Kyunghee LeeDaewon Jeong
Oct 26, 2018·Journal of Cellular and Molecular Medicine·Qianqian ZhengBiao Wang
Nov 6, 2018·Journal of Cellular Physiology·Boran CaoWenbo Wang
Sep 10, 2019·Journal of Leukocyte Biology·Pei YangLing-Ling Zhou
Jul 12, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dianshan KeJianming Hou
Nov 19, 2019·Oral Diseases·Lili WuLijia Guo
Jan 28, 2020·Bioscience, Biotechnology, and Biochemistry·Zhanhao XiaoYang Feng
Jul 7, 2019·Annals of the Rheumatic Diseases·Dennis G McGonagleRobert Moots
Apr 23, 2020·International Journal of Molecular Sciences·Viviana di GiacomoSilvia Sancilio
May 7, 2019·Molecular Medicine Reports·Lu SongLili Chen
May 7, 2020·Connective Tissue Research·Zhongxiu WangLili Chen
Jan 11, 2020·Frontiers in Immunology·Ting LiuJunfa Li
Jan 17, 2021·Journal of Cellular Physiology·Yi-Fan GuoXiang-Hang Luo
Dec 2, 2020·Archives of Oral Biology·Yukio OzakiAtsutoshi Yoshimura
Jan 16, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tingting LuoZhengjun Shang
Nov 18, 2020·Cells·Benjamin LaiJenn-Haung Lai
Jun 15, 2020·Ageing Research Reviews·Xu LiLing Qin
Feb 23, 2021·Frontiers in Immunology·Mengjia TangXijie Yu
Jun 19, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lingyun LuXijie Yu
Aug 3, 2021·Frontiers in Cellular and Infection Microbiology·Ming ChengZuoyao Huang
Aug 20, 2021·Expert Review of Clinical Immunology·Stephanie R Harrison, Helena Marzo-Ortega
Aug 17, 2021·Journal of Immunology Research·Jingyi TanLili Chen