IL-17F facilitates prostate cancer cell malignant phenotypes via activation of the PI3K/AKT signalling pathway.

Andrologia
Xu ZhuZhigang Cao

Abstract

Prostate cancer (PCa) is known as one of the most common cancers in men all over the world. Previous studies have identified that the pro-inflammatory mediator interleukin-17F (IL-17F) aggravates the progression of several diseases. However, whether IL-17F plays a role in PCa is still lack of enough exploration. In this study, IL-17F expression was strikingly upregulated in PCa tissues. Treatment of IL-17F promoted cell viability at a dose-dependent manner. Further, functional assays were implemented by treatment of 100 ng/ml of IL-17F. Cell viability, proliferation, migration, invasion and stemness were promoted by 100 ng/ml of IL-17F. IL-17F increased the expression of p-PI3K and p-AKT in PCa cells, indicating that IL-17F might activate the PI3K/AKT signalling pathway in PCa cells. LY294002 (the inhibitor of the PI3K/AKT signalling pathway) could reverse the facilitating effects of IL-17F treatment on PCa cell viability, proliferation, migration, invasion and stemness. Taken together, current study revealed that IL-17F facilitated PCa cell malignant phenotypes via activation of the PI3K/AKT signalling pathway, offering a potential therapeutic target for PCa.

References

Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M KawaguchiS K Huang
Apr 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Phyllis F Y CheungChristopher W K Lam
Jan 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Anna DubrovskaVenkateshwar A Reddy
Feb 24, 2009·Cytokine·Seon Hee Chang, Chen Dong
Nov 28, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Serena Di MeoEmma Di Carlo
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Oct 17, 2015·Annual Review of Medicine·Ingrid A Mayer, Carlos L Arteaga
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Sep 1, 2016·Experimental Dermatology·Trine BertelsenClaus Johansen
Jun 22, 2017·Scandinavian Journal of Urology·Jan AdamowiczSadegh Babashah
Dec 23, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiaoqiang SiShuyi Chenge

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