IL-18 gene polymorphisms affect IL-18 production capability by monocytes

Biochemical and Biophysical Research Communications
Junsuke ArimitsuToshio Tanaka

Abstract

We previously demonstrated a significant association between IL-18 gene polymorphism 105A/C and asthma. In this study, we investigated the relationship of IL-18 gene polymorphism to IL-18 production capability by monocytes. The frequency of gene polymorphisms including IL-18-105A/C and IL-18--137G/C was determined by PCR analyses. The IL-18 production by monocytes stimulated without or with LPS or A23187+PMA for 1day was measured by ELISA. The produced IL-18 spontaneously or in response to A23187+PMA by monocytes was significantly higher for volunteers with 105A/A genotype than with 105A/C genotype. Similarly, the production capability of IL-18 by monocytes from volunteers with -137G/G genotype was significantly higher than that with -137G/C genotype and significant linkage disequilibrium was observed between 105A/C and -137G/C polymorphism. Thus, the genetic capacity to produce more IL-18 in response to stimuli may affect the onset of asthma.

References

Jan 20, 1999·The Journal of Allergy and Clinical Immunology·C A Dinarello
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·T YoshimotoK Nakanishi
Aug 13, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S HigaT Tanaka
Mar 10, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A NietersN Becker
Apr 5, 2005·The Journal of Allergy and Clinical Immunology·Natalija NovakThomas Bieber

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Citations

Apr 24, 2009·Rheumatology International·Teresa WarchołPaweł Piotr Jagodziński
Apr 23, 2013·Human Immunology·Yuh-Cheng YangYann-Jinn Lee
Aug 30, 2012·European Journal of Human Genetics : EJHG·Simon R ThompsonKrishna R Veeramah
May 10, 2007·European Journal of Human Genetics : EJHG·Sandrine BarbauxLaurence Tiret
Jan 12, 2007·Genes and Immunity·S R Thompson, S E Humphries
Sep 11, 2008·The Journal of Infectious Diseases·Ping AnCheryl A Winkler
Jul 25, 2012·Viral Immunology·Marzyeh Amini, Hossein Poustchi
Nov 29, 2007·The Pediatric Infectious Disease Journal·Beena PuthothuAndrea Heinzmann
Feb 15, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Paola BossùGianfranco Spalletta
Oct 17, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Zhi-Gang LiWei-Wei Wu
Mar 23, 2010·Human Immunology·Lydie Izakovicova HollaAnna Vasku
Jan 26, 2010·Brain Research Bulletin·Na ZhangLan Tan
Nov 29, 2008·Cytokine & Growth Factor Reviews·Andrew J P Smith, Steve E Humphries
Apr 21, 2007·Metabolism: Clinical and Experimental·Simon R ThompsonSteve E Humphries
Mar 17, 2009·Journal of Clinical Laboratory Analysis·Shih-Yin ChenFuu-Jen Tsai
Aug 26, 2010·European Journal of Clinical Investigation·Jussi A HernesniemiTerho Lehtimäki
Jan 11, 2013·Journal of Gastroenterology and Hepatology·Shou-Chuan ShihYann-Jinn Lee
Jan 30, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·I PrestaG Sesti
Apr 13, 2011·Atherosclerosis·Barbara J M H JefferisPeter H Whincup
Dec 19, 2009·Scandinavian Journal of Urology and Nephrology·Kuang-Chi LaiWen-Chi Chen
Jul 6, 2014·BioMed Research International·Daye ChengYiran Ma

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