IL-18 receptor expression on epithelial cells is upregulated by TNF alpha

Inflammation
Eliska KrasnaIlja Striz

Abstract

IL-18 is a multifunctional cytokine that augments both innate and acquired immunity and potentiates Th1 and Th2 reactions. We studied the expression of IL-18 receptor (IL-18R) on renal and respiratory epithelial cell lines. Both cell lines upregulated IL-18R mRNA and IL-18R membrane expression in response to TNF alpha and other proinflammatory cytokines. The function of IL-18R was confirmed by induction of IL-8 release from epithelial cells in response to recombinant IL-18. Epithelial cells may represent an important target for IL-18, mainly under inflammatory conditions associated with TNF alpha release.

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Citations

May 13, 2006·American Journal of Respiratory Cell and Molecular Biology·Jamie H Rosenblum LichtensteinJoseph D Brain
Aug 10, 2007·Kidney International·S GauerI A Hauser
Apr 14, 2009·Transplantation Reviews·Christopher Y C Nguan, Caigan Du
May 28, 2019·Journal of Clinical Periodontology·Daniela B PaliotoManjunatha Benakanakere

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