IL-1alpha and IL-1ra secretion from epidermal equivalents and the prediction of the irritation potential of mild soap and surfactant-based consumer products

Toxicology in Vitro : an International Journal Published in Association with BIBRA
L BernhoferK M Martin

Abstract

We have previously evaluated the measurement of viability and cytokine release from skin equivalents, for predicting the skin irritation potential of topically applied surfactants and demonstrated that IL-1alpha and interleukin-1 receptor antagonist (IL-1ra) release from epidermal skin equivalents correlates with skin irritation potential. In this study, the utility of the model was confirmed by the evaluation of cleansing bars and cleansing lotions that exhibited varying degrees of irritation potential as determined by exaggerated arm wash human clinical studies. Epidermal equivalents were exposed to increasing concentrations of the cleansing bars and cleansing liquids and viability and release of IL-1alpha and IL-1ra were measured. Loss of viability was used to identify the stronger irritants of the products tested. A linear correlation was demonstrated between IL-1alpha and IL-1ra secretion and human irritation data, demonstrating that the model can correctly predict the irritation potential of soap and surfactant products. These results show that this in vitro model is useful for rank ordering the irritation potential of mild consumer products and for demonstrating enhanced mildness in products with minor differences.

References

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Citations

Feb 24, 2009·Annals of Biomedical Engineering·Lisette H CornelissenCees W J Oomens
Mar 30, 2004·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Thomas WelssKlaus R Schröder
Apr 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·L P BernhoferK M Martin
Mar 15, 2000·Journal of Pharmacological and Toxicological Methods·M K RobinsonM A Perkins
Sep 19, 2012·Dermatology Research and Practice·Lorena S TelofskiGeorgios N Stamatas
Jul 20, 2004·Skin Pharmacology and Physiology·A zur MühlenM Hermann
May 12, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Pankaj KarandeSamir Mitragotri
Mar 27, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Mitchell KlausnerJoseph Kubilus
Jun 20, 2007·Experimental Dermatology·Debbie BronnebergCatlijin V C Bouten
Jun 1, 2012·Expert Review of Dermatology·James Varani
Mar 27, 2018·Experimental Dermatology·Christian RiebelingTewes Tralau
Nov 18, 2000·Annals of the New York Academy of Sciences·M K RobinsonM A Perkins

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