IL-1RN and IL-1β Polymorphism and ARV-Associated Hepatotoxicity

Mediators of Inflammation
HariOm SinghRaman R Gangakhedkar

Abstract

The severity of hepatic injury depends upon cytokines. Previous studies associated IL-1RN allele 2 with IL-1β production. Hence, we examined the association of IL-1 RN and IL-1β polymorphisms with ARV-associated hepatotoxicity. Genotyping of IL-1RN (VNTR), IL-1β (-511C/T) polymorphisms was done in 162 HIV-infected patients, 34 with ARV hepatotoxicity, 128 without hepatotoxicity, and 152 healthy controls using PCR and PCR-RFLP method. The haplotypes 1T and 2C enhanced the risk for severe hepatotoxicity (OR = 1.41, P = 0.25; OR = 1.67, P = 0.31). IL-1β-511TT genotype significantly represented among tobacco using HIV-infected individuals compared to nonusers (OR = 3.74, P = 0.05). IL-1β-511TT genotype among alcohol users increased the risk for hepatotoxicity (OR = 1.80, P = 0.90). IL-1β-511CT and -511TT genotypes overrepresented in alcohol using HIV-infected individuals (OR = 2.29, P = 0.27; OR = 2.64, P = 0.19). IL-RN 2/2 and 1/3 genotypes represented higher in nevirapine using hepatotoxicity patients (OR = 1.42, P = 0.64, OR = 8.79, P = 0.09). IL-1β-511CT and -511 TT genotypes among nevirapine users enhanced the risk for severe hepatotoxicity (OR = 4.29, P = 0.20; OR = 1.95, P = 0.56). IL-1β-511CT and -511TT genotypes were overr...Continue Reading

References

Sep 1, 1992·Human Molecular Genetics·F S di GiovineG W Duff
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S P EisenbergR C Thompson
Jan 1, 1991·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·M S MeltzerH E Gendelman
Nov 1, 1990·The Journal of Experimental Medicine·H E GendelmanC Dieffenbach
Oct 1, 1980·American Journal of Epidemiology·S Greenland
May 1, 1994·Research in Virology·W GlienkeH Rübsamen-Waigmann
Jan 9, 1998·Drug Metabolism Reviews·E T Morgan
May 23, 1998·Annual Review of Immunology·W P ArendC Gabay
Jul 1, 1998·International Reviews of Immunology·C A Dinarello
Jan 8, 2000·The Journal of Biological Chemistry·D E SmithJ E Sims
May 23, 2002·Seminars in Liver Disease·Neil Kaplowitz
Nov 15, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Megan E O'BrienPatricia Kissinger
Jan 13, 2006·Annual Review of Pharmacology and Toxicology·Alison E AitkenEdward T Morgan
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vito Racanelli, Barbara Rehermann
Aug 2, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jeffrey H SametRichard Saitz
Mar 13, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·H SinghB Mittal
Mar 18, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Victor AsensiEulalia Valle-Garay
Nov 13, 2008·The Journal of Infectious Diseases·Russell B Van DykeUNKNOWN Pediatric AIDS Clinical Trials Group 219C Team
Nov 19, 2008·Chemico-biological Interactions·Yasuhiro MasubuchiToshiharu Horie
Jun 6, 2009·The New England Journal of Medicine·Charles A Dinarello
Jan 21, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Enitan D CarrolWilliam E Ollier
Oct 4, 2011·Indian Journal of Clinical Biochemistry : IJCB·Pravin Kesarwani, Rama D Mittal
Apr 7, 2016·Scientific Reports·Jiawei ShenYongyong Shi

❮ Previous
Next ❯

Methods Mentioned

BETA
fluorescence-activated cell sorting
PCR

Software Mentioned

SPSS
SHEsisPlus

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.