IL-2-induced proliferative response is controlled by loci Cinda1 and Cinda2 on mouse chromosomes 11 and 12: a distinct control of the response induced by different IL-2 concentrations

Genomics
M KrulováMarie Lipoldová

Abstract

Lymphocytes of mouse strains BALB/cHeA (BALB/c) and STS/A (STS) differ in the IL-2-induced proliferative response, STS being a high and BALB/c a low responder in the range of concentrations 125-2000 IE/ml. We analyzed the genetic basis of this strain difference using the recombinant congenic (RC) strains of the BALB/c-c-STS/Dem (CcS/Dem) series. This series comprises 20 homozygous strains all derived from two parental inbred strains: the "background" strain BALB/c and the "donor" strain STS. Each CcS/Dem strain contains a different, random set of approximately 12.5% genes of the donor strain STS and approximately 87.5% genes of the background strain BALB/c. In this way, the STS genes controlling the IL-2-induced response became separated into individual CcS/Dem strains, as indicated by differences in the magnitude of the IL-2-induced response among CcS/Dem strains (M. Lipoldová et al., 1995, Immunogenetics 41: 301-311). To map some of these genes, we tested F2 hybrids between one of the high-responder RC strains, CcS-4, and the low-responder parental strain BALB/c. We found that the response to high IL-2 concentrations is controlled by a locus, Cinda1 (cytokine-induced activation 1), on chromosome 11 near the marker D11Mit4. Th...Continue Reading

References

Jul 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P C GrootP Demant
Jan 1, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C J MoenP Demant
Aug 11, 1991·Nucleic Acids Research·P W LairdA Berns
Jun 1, 1994·Current Opinion in Immunology·J P Allison
Jan 1, 1995·Annual Review of Immunology·D M Pardoll
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C BeadlingK A Smith
Jan 1, 1995·Genetics·G H LeeN R Drinkwater
Sep 30, 1994·Science·E S Lander, N J Schork
Jan 1, 1993·Annual Review of Immunology·Y MinamiT Taniguchi
Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·C J MoenP Demant
Nov 1, 1995·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C A Kozak, W J Leonard
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·M C FriedmannW J Leonard
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·J D GorhamK M Murphy
Jan 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·A P StassenP Demant
Nov 22, 1996·Science·P DemantM Svobodova

❮ Previous
Next ❯

Citations

Mar 26, 2003·Infection and Immunity·Vladimir VladimirovMarie Lipoldová
Jul 23, 2013·PLoS Neglected Tropical Diseases·Yahya SohrabiMarie Lipoldová
Sep 15, 2004·The Journal of Biological Chemistry·Jean G SathishR James Matthews
Nov 30, 2016·Biology of Sex Differences·Martina SlapničkováMarie Lipoldová

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.