IL-2 producing memory CD4+ T lymphocytes are closely associated with the generation of IgG-secreting plasma cells

The Journal of Immunology : Official Journal of the American Association of Immunologists
Nicolle H R LitjensMichiel G H Betjes

Abstract

The role of specific CD4(+) T cell subsets in the induction of humoral immune responses in humans is largely unknown. In this study, the generation of hepatitis B surface Ag-specific CD4(+) T lymphocytes following vaccination was closely monitored and characterized at the single-cell level. The appearance and absolute numbers of hepatitis B surface Ag-specific IL-2 producing effector memory CD4(+) T lymphocytes was solely and tightly related to Ab titers reached. This relation remained present many years after vaccination. Subsequently, a relation was found between Ab titers and number of IL-2 producing memory CD4(+) T lymphocytes for various other Ags. These observations matched the findings of an in vitro assay, using different T cell subsets to induce B cell differentiation into IgG-producing plasma cells. By depleting for IL-2 producing memory T cells, we demonstrated that these cells are important for B cell differentiation into IgG-producing plasma cells. Finally, blocking the action of IL-2 with an IL-2R-alpha Ab inhibited the differentiation of B lymphocytes into IgG-producing plasma cells. Based on these findings, we conclude that the development of Ag-specific IL-2-producing memory T cells appears to be essential for ...Continue Reading

References

Aug 1, 1994·European Journal of Immunology·V FernandezM Troye-Blomberg
Oct 31, 1996·Nature·A K AbbasA Sher
Jul 10, 1997·Nature·R A ManzA Radbruch
Apr 7, 1998·Immunity·M K SlifkaR Ahmed
Dec 18, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·T PropstP König
May 4, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R M Zinkernagel
Mar 3, 2001·Current Opinion in Immunology·J Sprent, C D Surh
May 11, 2002·Nature Reviews. Immunology·Susan M KaechRaft Ahmed
Dec 14, 2002·Science·Nadia L BernasconiAntonio Lanzavecchia
Aug 28, 2003·Nature Immunology·Robert A Seder, Rafi Ahmed
Dec 5, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gerald DaRozaAdeera Levin
Mar 23, 2004·Annual Review of Immunology·Federica SallustoAntonio Lanzavecchia
Oct 21, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephen C De RosaMario Roederer
Nov 1, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Nicolle H R LitjensMichiel G H Betjes
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anagha A DivekarTim R Mosmann
Sep 29, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Martijn Anton VerkadeMichiel Gerardus Henricus Betjes
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Muriel StubbeArnaud Marchant
Feb 13, 2007·Current Opinion in Immunology·Axel Kallies, Stephen L Nutt
Jun 26, 2007·Scandinavian Journal of Immunology·S AmuM Brisslert
Jun 29, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michiel G H BetjesRobert Zietse
Jul 20, 2007·Clinical and Vaccine Immunology : CVI·Catherine BarbeyFrançois Spertini
Oct 16, 2007·European Journal of Immunology·Fabio BergaminKenneth C McCullough

❮ Previous
Next ❯

Citations

Sep 20, 2011·The Journal of Clinical Investigation·Julien van GrevenyngheElias K Haddad
May 4, 2012·The Journal of Infectious Diseases·Gabriel K PedersenRebecca J Cox
Jan 24, 2015·Biomolecules·David A Jackson, Sherine F Elsawa
Sep 22, 2017·Human Vaccines & Immunotherapeutics·Philippe MorisRobbert G van der Most
Apr 25, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark S de SouzaUNKNOWN Ministry of Public Health–Thai AIDS Vaccine Evaluation Group Collaborators
Jul 23, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erika Garner-SpitzerUrsula Wiedermann
Sep 14, 2012·Immunity & Ageing : I & a·Ruud Wj MeijersMichiel Gh Betjes
Jul 7, 2015·Human Vaccines & Immunotherapeutics·Jack A PanapasaKarl A Brokstad
May 3, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michiel G H BetjesNicolle H R Litjens
May 29, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simon Le GallouThierry Fest
Mar 20, 2013·Nature Reviews. Nephrology·Michiel G H Betjes
Apr 29, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicolle H R LitjensMichiel G H Betjes
Dec 23, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicolle H R LitjensMichiel G H Betjes
Aug 12, 2021·Transplantation Proceedings·Michiel G H BetjesJoke I Roodnat
Apr 17, 2009·Vaccine·Rebecca J CoxLars R Haaheim
Sep 28, 2021·Frontiers in Medicine·Jiachuan XiongJinghong Zhao

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Muriel StubbeArnaud Marchant
International Journal of Immunopathology and Pharmacology
G LanzilliM P Fuggetta
The Journal of Immunology : Official Journal of the American Association of Immunologists
Miranda E A T van BerkelMariëtte A Oosterwegel
The Journal of Immunology : Official Journal of the American Association of Immunologists
Arnold P J van der MarelReina E Mebius
The Journal of Immunology : Official Journal of the American Association of Immunologists
Victor AppaySarah L Rowland-Jones
© 2022 Meta ULC. All rights reserved