PMID: 15240677Jul 9, 2004Paper

IL-21 enhances and sustains CD8+ T cell responses to achieve durable tumor immunity: comparative evaluation of IL-2, IL-15, and IL-21

The Journal of Immunology : Official Journal of the American Association of Immunologists
Adrianna MorozProtul A Shrikant

Abstract

Cytokines that use the common receptor gamma-chain for regulating CD8(+) T cell responses to Ag include IL-2, IL-15, and the recently identified IL-21. The ability of these cytokines to regulate antitumor activity in mice has generated considerable interest in understanding their mode of action. In this study we compare the abilities of IL-2, IL-15, and IL-21 to stimulate immunity against tumors in a syngeneic thymoma model. Durable cures were only achieved in IL-21-treated mice. By monitoring both endogenous and adoptively transferred tumor Ag-specific CD8(+) T cells, it was determined that IL-21 activities overlap with those of IL-2 and IL-15. Similar to IL-2, IL-21 enhanced Ag activation and clonal expansion. However, unlike IL-2 treatment, which induces activation-induced cell death, IL-21 sustained CD8(+) T cell numbers long term as a result of increased survival, an effect often attributed to IL-15. These findings indicate that the mechanisms used by IL-21 to promote CD8(+) T cell responses offer unique opportunities for its use in malignant diseases and infections.

References

Aug 1, 1993·European Journal of Immunology·J KirbergH von Boehmer
Mar 31, 1999·Immunology Today·T R MalekY W He
Mar 23, 2001·Nature Immunology·K S SchlunsL Lefrançois
Jan 3, 2001·Nature Medicine·X C LiT B Strom
Jul 12, 2001·Proceedings of the National Academy of Sciences of the United States of America·J T TanC D Surh
Aug 30, 2001·Proceedings of the National Academy of Sciences of the United States of America·R M KedlS Dow
Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ee Loon ThamMatthew F Mescher
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gülçin DemirciXian Chang Li
May 3, 2002·Blood·Anne-Tove BrenneHenrik Hjorth-Hansen
Jun 19, 2002·The Journal of Experimental Medicine·Martin PrlicStephen C Jameson
Jul 23, 2002·Trends in Immunology·Byungsuk KwonByoung S Kwon
Aug 3, 2002·Nature Reviews. Immunology·Stephen C Jameson
Aug 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Protul Shrikant, Matthew F Mescher
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mari StrengellSampsa Matikainen
Nov 26, 2002·Science·Katsutoshi OzakiWarren J Leonard
Dec 10, 2002·Cellular Immunology·Matthias EberlHassan Jomaa
Dec 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jodi GoldbergMatthew F Mescher
Apr 2, 2003·Nature Reviews. Immunology·Kimberly S Schluns, Leo Lefrançois
Apr 15, 2003·Nature Medicine·Joseph N BlattmanRafi Ahmed
May 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marion BerardDavid F Tough
May 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mari StrengellTimo Sareneva
Jun 6, 2003·Current Opinion in Immunology·Lewis L Lanier
Jul 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hak-Ling MaKyriaki Dunussi-Joannopoulos
Oct 8, 2003·Molecular Therapy : the Journal of the American Society of Gene Therapy·Tsunao KishidaOsam Mazda

❮ Previous
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Citations

Feb 25, 2005·Springer Seminars in Immunopathology·Morgan E Wallace, Mark J Smyth
Aug 6, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rayna TakakiLewis L Lanier
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alberto ComesSilvano Ferrini
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julie M RodaWilliam E Carson
Feb 8, 2007·Cancer Immunology, Immunotherapy : CII·Henrik SøndergaardMichael Kragh
Dec 16, 2006·International Reviews of Immunology·John Copier, Angus Dalgleish
Sep 28, 2007·International Immunology·Shujuan LiuPatrick Hwu
Feb 21, 2008·Cancer Immunology, Immunotherapy : CII·Klaus Stensgaard FrederiksenKresten Skak
Sep 9, 2008·Expert Opinion on Biological Therapy·Kim Margolin
Feb 9, 2008·Nature Reviews. Drug Discovery·Kresten SkakPallavur V Sivakumar
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Audrey L KinterAnthony S Fauci
Oct 23, 2009·Tissue Antigens·H Søndergaard, K Skak
Feb 12, 2010·Expert Opinion on Biological Therapy·Miriam CoccorisReno Debets
Sep 29, 2011·Journal of Translational Medicine·Chantal MengusStephen Wyler
Dec 18, 2013·Immunological Reviews·Marcus O Butler, Naoto Hirano
May 16, 2014·Journal for Immunotherapy of Cancer·Shailender BhatiaJohn A Thompson
May 12, 2015·Journal of Immunology Research·Michela CroceSilvano Ferrini
Mar 29, 2016·Genetics Research International·Farzaneh RamiMansoor Salehi
Dec 20, 2017·Autoimmunity·Rafaela Silva Guimarães GonçalvesMaira Galdino R Pitta
May 17, 2019·Immunotherapy·Parnian JabbariNima Rezaei
Apr 21, 2007·Cancer Immunology, Immunotherapy : CII·Emma di CarloSilvano Ferrini
May 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark J SmythKazuyoshi Takeda
Aug 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Monika KasprzyckaMariusz A Wasik
Jul 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nuno L AlvesRené A W van Lier
Jul 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guobing ChenM Frances Shannon
Nov 17, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Henrik SøndergaardMark J Smyth
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elizabeth BolestaDanuta Kozbor
Dec 16, 2006·International Reviews of Immunology·Frédéric Lévy, Sara Colombetti
Feb 7, 2009·Expert Review of Vaccines·Luiz Rodrigues, Cristina Bonorino
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rosanne SpolskiWarren J Leonard
Jul 26, 2008·Journal of Leukocyte Biology·Thomas Y WuestArthur A Hurwitz

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