IL-22 Promotes IFN-γ-Mediated Immunity against Histoplasma capsulatum Infection.

Biomolecules
Morgana K B PradoLúcia H Faccioli

Abstract

Histoplasma capsulatum is the agent of histoplasmosis, one of the most frequent mycoses in the world. The infection initiates with fungal spore inhalation, transformation into yeasts in the lungs and establishment of a granulomatous disease, which is characterized by a Th1 response. The production of Th1 signature cytokines, such as IFN-γ, is crucial for yeast clearance from the lungs, and to prevent dissemination. Recently, it was demonstrated that IL-17, a Th17 signature cytokine, is also important for fungal control, particularly in the absence of Th1 response. IL-22 is another cytokine with multiple functions on host response and disease progression. However, little is known about the role of IL-22 during histoplasmosis. In this study, we demonstrated that absence of IL-22 affected the clearance of yeasts from the lungs and increased the spreading to the spleen. In addition, IL-22 deficient mice (Il22-/-) succumbed to infection, which correlated with reductions in the numbers of CD4+ IFN-γ+ T cells, reduced IFN-γ levels, and diminished nitric oxide synthase type 2 (NOS2) expression in the lungs. Importantly, treatment with rIFN-γ mitigated the susceptibility of Il22-/- mice to H. capsulatum infection. These data indicate th...Continue Reading

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Citations

Jan 12, 2021·Frontiers in Cellular and Infection Microbiology·Juan David Puerta-AriasÁngel González

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Methods Mentioned

BETA
PMA
ELISA
flow cytometry

Software Mentioned

MultiQuant
Graphpad Prism
PeakView
FlowJo
ImageJ
Prism

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