IL-22 Protects Against Liver Pathology and Lethality of an Experimental Blood-Stage Malaria Infection.

Frontiers in Immunology
Béatris MastelicJean Langhorne

Abstract

The host response following malaria infection depends on a fine balance between levels of pro-inflammatory and anti-inflammatory mediators resulting in the resolution of the infection or immune-mediated pathology. Whilst other components of the innate immune system contribute to the pro-inflammatory milieu, T cells play a major role. For blood-stage malaria, CD4(+) and γδ T cells are major producers of the IFN-γ that controls parasitemia, however, a role for TH17 cells secreting IL-17A and other cytokines, including IL-17F and IL-22 has not yet been investigated in malaria. TH17 cells have been shown to play a role in some protozoan infections, but they also are a source of pro-inflammatory cytokines known to be involved in protection or pathogenicity of infections. In the present study, we have investigated whether IL-17A and IL-22 are induced during a Plasmodium chabaudi infection in mice, and whether these cytokines contribute to either protection or to pathology induced during the infection. Although small numbers of IL-17- and IL-22-producing CD4 T cells are induced in the spleens of infected mice, a more pronounced induction is observed in the liver, where increases in mRNA for IL-17A and, to a lesser extent, IL-22 were o...Continue Reading

Citations

Sep 14, 2013·Seminars in Immunopathology·Jörg Stange, Marc Veldhoen
Jan 19, 2013·Annals of the Rheumatic Diseases·Jan Piet van HamburgErik Lubberts
Jul 12, 2013·European Journal of Immunology·Hidekazu IshidaHajime Hisaeda
Aug 28, 2013·Medical Hypotheses·Yuri Chaves Martins, Cláudio Tadeu Daniel-Ribeiro
Jan 9, 2016·Molecular Biology and Evolution·Margaret J MackinnonThomas N Williams
Feb 24, 2015·Annual Review of Immunology·Jarrod A DudakovMarcel R M van den Brink
Jan 30, 2015·Frontiers in Immunology·Damian Perez-Mazliah, Jean Langhorne
Nov 20, 2014·Frontiers in Microbiology·Frank WunderlichMohamed A Dkhil
Jun 18, 2016·Scientific Reports·Julie SellauThomas Jacobs
Dec 15, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Samad A IbitokouRobin Stephens
Jan 16, 2018·Nature Reviews. Immunology·Cevayir CobanKen J Ishii
Jun 3, 2014·BMC Immunology·Erika van den BogaartHenk D F H Schallig
Jan 1, 2014·Nature Reviews. Drug Discovery·Robert SabatKerstin Wolk
Jan 24, 2019·Annual Review of Immunology·Rui MartinsMiguel P Soares
Oct 1, 2020·The Journal of Experimental Medicine·Mary KeirNico Ghilardi
Apr 4, 2019·Nature Reviews. Immunology·Samarchith P KurupJohn T Harty
Mar 10, 2020·Mediators of Inflammation·Nada H AljarbaAhmed A Al-Qahtani
Dec 31, 2014·World Journal of Gastroenterology : WJG·Elisabetta CeniAndrea Galli
May 2, 2018·Clinical & Translational Immunology·Saleh Y AlabbasIulia Oancea
Mar 16, 2019·Frontiers in Immunology·Daria L IvanovaJason P Gigley
Jan 5, 2017·Journal of Immunology Research·Muhammad Babar KhawarKhawaja Abdul Mujeeb
Dec 18, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Leonard BlumSusanne Schiffmann
Apr 15, 2021·Seminars in Immunopathology·Jöran LückeSamuel Huber
Jan 29, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·María Carolina Amezcua VeselyEva Virginia Acosta Rodríguez
Oct 8, 2021·Cell Metabolism·Mark A Febbraio, Michael Karin

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Methods Mentioned

BETA
flow cytometry
FCS
PMA
PCR
FACS
ELISA

Software Mentioned

Summit
[UNK] Pro
FlowJo

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