IL-22BP is produced by eosinophils in human gut and blocks IL-22 protective actions during colitis

Mucosal Immunology
J C MartinR Josien

Abstract

Crohn's disease and ulcerative colitis, the two major forms of inflammatory bowel diseases (IBDs), are characterized by high levels of IL-22 production. Rodent studies revealed that this cytokine is protective during colitis but whether this is true in IBDs is unclear. We show here that levels of the soluble inhibitor of IL-22, interleukin 22-binding protein (IL-22BP), are significantly enhanced during IBDs owing to increased numbers of IL-22BP-producing eosinophils, that we unexpectedly identify as the most abundant source of IL-22BP protein in human gut. In addition, using IL-22BP-deficient rats, we confirm that endogenous IL-22BP is effective at blocking protective actions of IL-22 during acute colitis. In conclusion, our study provides new important insights regarding the biology of IL-22 and IL-22BP in the gut and indicates that protective actions of IL-22 are likely to be suboptimal in IBDs thus making IL-22BP a new relevant therapeutic target.Mucosal Immunology advance online publication, 2 September 2015; doi:10.1038/mi.2015.83.

References

Sep 18, 1999·Digestive Diseases and Sciences·E GaudioR Caprilli
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L DumoutierJ C Renauld
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·W XuD C Foster
Jan 7, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Naomi J LogsdonMark R Walter
Mar 16, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Stephan BrandJulia Dambacher
Dec 23, 2008·Immunity·Lauren A ZenewiczRichard A Flavell
Mar 11, 2009·The Journal of Experimental Medicine·Melanie A KleinschekRobert A Kastelein
Jul 1, 2009·The Journal of Experimental Medicine·Geethanjali PickertChristoph Becker
Jul 25, 2009·Science·Aron M GeurtsRoland Buelow
Oct 20, 2009·Cell·Ivaylo I IvanovDan R Littman
Mar 3, 2010·Annual Review of Immunology·Arthur KaserRichard S Blumberg
Apr 27, 2011·The Journal of Experimental Medicine·Masahito KamanakaRichard A Flavell
Apr 27, 2011·The American Journal of Gastroenterology·Bernadette BegueFrank M Ruemmele
May 18, 2011·The Journal of Experimental Medicine·Alessandra GeremiaFiona Powrie
Dec 1, 2009·Current Protocols in Pharmacology·Joseph R MaxwellJoanne L Viney
Sep 1, 2012·The Journal of Allergy and Clinical Immunology·James J LeeNancy A Lee
Nov 8, 2012·Current Opinion in Gastroenterology·Simon P HoganPatricia C Fulkerson
Apr 16, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lauren A ZenewiczRichard A Flavell
Apr 27, 2013·Nature Reviews. Immunology·Nobuhiko KamadaGabriel Núñez
Jun 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Carlene L ZindlCasey T Weaver
Jan 1, 2014·Nature Reviews. Drug Discovery·Robert SabatKerstin Wolk
Jan 8, 2014·The Journal of Experimental Medicine·Radha RameshMark S Sundrud
Jul 16, 2014·The Journal of Experimental Medicine·Randy S LongmanDan R Littman
Jul 23, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·YunJae Jung, Marc E Rothenberg
Dec 11, 2014·Mucosal Immunology·A J Macpherson, K D McCoy

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Citations

Jan 23, 2016·Frontiers in Cell and Developmental Biology·Olivia B ParksMisty Good
May 6, 2016·Frontiers in Immunology·Baptiste LamarthéeBéatrice Gaugler
Mar 1, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Mirna Perusina LanfrancaTimothy Frankel
Jun 16, 2016·Frontiers in Immunology·Silvia Gimeno BriasIan R Humphreys
Nov 16, 2016·Science·Penelope PelczarSamuel Huber
Oct 28, 2017·Journal of Gastroenterology·Atsushi MizoguchiEmiko Mizoguchi
Feb 3, 2018·International Immunology·Koichi HiroseHiroshi Nakajima
Mar 25, 2018·Scientific Reports·Stefanos VoglisFlorian C Kurschus
Apr 1, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel SwaffordSanthakumar Manicassamy
Nov 10, 2017·Frontiers in Immunology·Jan KempskiSamuel Huber
Mar 31, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jérôme C MartinRégis Josien
Jul 1, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jason OssartCarole Guillonneau
Jun 29, 2018·Clinical Pharmacology and Therapeutics·Michael E RothenbergTimothy T Lu
Mar 29, 2019·Biological & Pharmaceutical Bulletin·Hye-Lim KimSoo-Woong Lee
Sep 30, 2016·Science Signaling·Chrissie LimRam Savan
May 13, 2017·Frontiers in Immunology·Nicola L DinyDaniela Čiháková
Apr 10, 2019·Cell Death & Disease·Boning ZengFeiyue Xing
Nov 11, 2017·Seminars in Immunopathology·Mario WitkowskiSamuel Huber
Nov 8, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dörte KleinschmidtSamuel Huber
Oct 3, 2020·Cells·Morsal SabihiSamuel Huber
Aug 2, 2019·World Journal of Gastroenterology : WJG·Alexandre Loktionov
Jan 9, 2019·Frontiers in Immunology·Paloma Gómez-FernándezKoen Vandenbroeck
May 22, 2019·International Journal of Molecular Sciences·Paloma Gómez-FernándezKoen Vandenbroeck
Oct 13, 2020·Frontiers in Immunology·Tanzeela ArshadVaclav Liska
Apr 15, 2021·Seminars in Immunopathology·Jöran LückeSamuel Huber
May 8, 2021·Frontiers in Genetics·Vanessa ChenouardIgnacio Anegon
Jul 3, 2021·Journal of Clinical Medicine·Martyna TyszkaGrzegorz Władysław Basak
Jul 21, 2021·Cellular and Molecular Gastroenterology and Hepatology·Athanasia ApostolouKatia Karalis

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