IL-23 and IL-12p70 production by monocytes and dendritic cells in primary HIV-1 infection

Journal of Leukocyte Biology
Stéphanie LouisAnne Hosmalin

Abstract

IL-12 enhances protective responses against HIV replication. Its production after in vitro stimulation is defective in chronic HIV infection, but higher responses can be found. IL-23 shares the p40 chain and some properties with IL-12 and enhances Th17 responses, but its role in HIV infection is unknown. The production of IL-12 and IL-23 and the respective contribution of monocytes and myeloid conventional DC (cDCs) during primary HIV infection were determined. Sixteen patients included in the French PRIMO-ANRS Cohort without antiretroviral treatment were followed prospectively and compared with uninfected donors. Intracellular p40 expression by monocytes and cDCs, analyzed by flow cytometry, was transiently increased in monocytes and cDCs in response to LPS and more consistently, in monocytes in response to LPS + IFN-gamma. IL-23 production, measured by ELISA after PBMC stimulation, was induced by LPS in strong correlation with VLs. IL-12p70 production required the addition of IFN-gamma and was transiently increased in patients compared with controls in correlation with VLs, whereas IL-23 was increased sustainedly. Therefore, an apparent domination of IL-23 over IL-12 responses occurred throughout primary HIV infection, and a ...Continue Reading

References

Apr 1, 1994·The Journal of Experimental Medicine·J ChehimiG Trinchieri
Sep 1, 1993·AIDS·A SiniccoP Gioannini
Jan 1, 1996·The Journal of Experimental Medicine·X MaG Trinchieri
Apr 1, 1998·European Journal of Immunology·C ChougnetG M Shearer
Nov 24, 1999·The Journal of Clinical Investigation·M DalodA Venet
Dec 5, 2002·Current Molecular Medicine·C ServetA Hosmalin
Dec 4, 2003·Nature Reviews. Immunology·Martien L Kapsenberg
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rui ZhangClaire Chougnet
Jun 18, 2005·The Journal of Infectious Diseases·Isabelle KamgaAnne Hosmalin
Aug 17, 2006·AIDS Research and Human Retroviruses·Philip J NorrisMichael P Busch
Nov 28, 2006·Trends in Immunology·Andrea M Cooper, Shabaana A Khader
May 21, 2008·The Journal of Experimental Medicine·Franca GerosaGiorgio Trinchieri
Jul 16, 2008·AIDS Research and Human Retroviruses·Janak KoiralaRichard M Novak
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robert E RosesBrian J Czerniecki
Jan 24, 2009·Immunological Reviews·Lyudmila LyakhFranca Gerosa
Apr 18, 2009·Microbes and Infection·Federica Sallusto, Antonio Lanzavecchia

❮ Previous
Next ❯

Citations

Sep 10, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·V SugithariniE Berla Thangam
Sep 29, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Govardhana Rao YannamLarisa Y Poluektova
Jan 21, 2012·Scandinavian Journal of Immunology·Y Bi, R Yang
Feb 12, 2011·Biochimica Et Biophysica Acta·Petra GyntherSami Väisänen
Jul 29, 2010·Vaccine·Katerina SkalovaJaroslav Michalek
Jan 24, 2018·Biology Open·Raghubendra Singh DagurLarisa Y Poluektova
Apr 18, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Charles-Antoine DutertreAnne Hosmalin
Jun 24, 2016·Journal of Virology·Aaron Christensen-QuickAlfredo Garzino-Demo
Mar 21, 2020·Journal of Neurovirology·Naomi SwantaKathleen Borgmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.