IL-23 Contributes to Control of Chronic Helicobacter Pylori Infection and the Development of T Helper Responses in a Mouse Model.

Frontiers in Immunology
Dennis J HorvathHolly M Scott Algood

Abstract

The immune response to Helicobacter pylori involves a mixed T helper-1, T helper-2, and T helper-17 response. It has been suggested that T helper cells contribute to the gastric inflammatory response during infection, and that T helper 1 (Th1) and T helper 17 (Th17) subsets may be required for control of H. pylori colonization in the stomach. The relative contributions of these subsets to gastritis and control of infection are still under investigation. IL-23 plays a role in stabilizing and expanding Th17 cell cytokine expression. Expression of IL-23, which is induced in dendritic cells and macrophages following co-culture with H. pylori, has also been reported to increase during H. pylori infection in humans and animal models. To investigate the role of IL-23 in H. pylori, we infected IL-23p19 deficient mice (IL-23-/-) and wild-type littermates with H. pylori strain SS1. At various time points post-infection, we assessed colonization, gastric inflammation, and cytokine profiles in the gastric tissue. Specifically, H. pylori-infected IL-23-/- mice have higher levels of H. pylori in their stomachs, significantly less chronic gastritis, and reduced expression of IL-17 and IFNγ compared to H. pylori-infected wild-type mice. While ...Continue Reading

Citations

Nov 21, 2013·Gut Microbes·Shamila ZawahirThomas G Blanchard
Feb 6, 2013·Gut Microbes·Dacie R Bridge, D Scott Merrell
Nov 12, 2014·Frontiers in Microbiology·Steve Oghumu, Abhay Satoskar
Feb 11, 2016·World Journal of Clinical Pediatrics·Li-Jing Xiong, Meng Mao
Feb 3, 2018·Gastroenterology Research and Practice·Piyumali Sandareka ArachchiChinthika Prabhashinie Gunasekara
Aug 21, 2019·Infection and Immunity·Beverly R E A DixonHolly M Scott Algood
Sep 3, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Taslima T LinaVictor E Reyes
Sep 18, 2013·Helicobacter·Manuel KochSteven F Moss
Sep 4, 2015·Cellular Microbiology·Trevelyan R MenheniottAndrew S Giraud
May 1, 2021·International Journal of Molecular Sciences·Svetlana KononovaStanislav Sitkin

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BETA
PCR

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Searchlight System
GraphPad Prism

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