IL-23 dampens the allergic response to Cryptococcus neoformans through IL-17-independent and -dependent mechanisms.

The American Journal of Pathology
Wendy A SzymczakLiise-anne Pirofski

Abstract

The cytokines IL-23 and IL-17 have been implicated in resistance to cryptococcal disease, but it is not clear whether IL-23-mediated production of IL-17 promotes fungal containment following pulmonary challenge with Cryptococcus neoformans. We used mice lacking IL-23 (IL-23p19(-/-)) or IL-17RA (IL-17RA(-/-)), and wild type (WT) C57BL/6 mice to examine the IL-23/IL-17 axis after intranasal infection with the C. neoformans strain 52D. The absence of IL-23 or IL-17RA had no effect on pulmonary or brain fungal burden at 1 or 6 weeks after infection. However, survival of IL-23p19(-/-) mice was reduced compared to IL-17RA(-/-) mice. IL-I7 production by CD4 T cells and natural killer T (NKT) cells was impaired in IL-23p19(-/-) lungs, but was not completely abolished. Both IL-23p19(-/-) and IL-17RA(-/-) mice exhibited impaired neutrophil recruitment, increased serum levels of IgE and IgG2b, and increased deposition of YM1/YM2 crystals in the lung, but only IL-23p19(-/-) mice developed persistent lung eosinophilia. Although survival of IL-17RA(-/-) and WT mice was similar after 17 weeks of infection, only surviving IL-17RA(-/-) mice exhibited cryptococcal dissemination to the blood. These data demonstrate that IL-23 dampens the allergic...Continue Reading

References

Mar 1, 1978·Veterinary Pathology·J M Ward
Apr 1, 1991·The Journal of Clinical Investigation·R H GundelG J Gleich
Jul 1, 1974·The Journal of Infectious Diseases·W R SalyerR D Baker
May 1, 1996·Clinical and Experimental Immunology·K KawakamiA Saito
Jun 1, 1996·The Journal of Experimental Medicine·F FossiezS Lebecque
Oct 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K D MillerR T Davey
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·R R YuanM D Scharff
Sep 1, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P VengeA Trulson
Mar 14, 2000·The Journal of Biological Chemistry·L GuoJ C Schuh
Apr 16, 2002·AIDS·Neil FrenchCharles F Gilks
Nov 6, 2002·The Journal of Biological Chemistry·Sudeepta AggarwalAustin L Gurney
Aug 27, 2005·Immunologic Research·Shikha Arora, Gary B Huffnagle
Sep 13, 2006·Veterinary Pathology·M J HoenerhoffJ M Ward
Oct 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Patricia C FulkersonMarc E Rothenberg
Mar 6, 2007·The Journal of Allergy and Clinical Immunology·Alexandra F FreemanSteven M Holland
Apr 4, 2007·Infection and Immunity·Xiaowen L RudnerJudd E Shellito
Jul 12, 2007·Proceedings of the National Academy of Sciences of the United States of America·Akihiro KimuraTadamitsu Kishimoto
Sep 21, 2007·The New England Journal of Medicine·Steven M HollandBodo Grimbacher
Oct 26, 2007·Clinical and Vaccine Immunology : CVI·D C SahaN Singh
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erika A RickelAlison L Budelsky
Sep 13, 2008·American Journal of Respiratory and Critical Care Medicine·Hidefumi WakashinHiroshi Nakajima
Dec 31, 2008·The Journal of Experimental Medicine·Hiroaki TakatoriJohn J O'Shea
May 28, 2009·The Journal of Infectious Diseases·George S Deepe, Reta S Gibbons
Sep 1, 2009·Current Opinion in Immunology·Yoshiyuki Minegishi
Dec 3, 2009·International Immunology·Melanie A KleinschekGottfried Alber

❮ Previous
Next ❯

Citations

Sep 5, 2014·European Journal of Immunology·Bianca SchulzeGottfried Alber
Jun 4, 2015·American Journal of Respiratory Cell and Molecular Biology·Jennifer K ColbyBruce D Levy
Dec 22, 2015·Nature Reviews. Microbiology·Robin C MayKirsten Nielsen
Oct 15, 2013·Biological Reviews of the Cambridge Philosophical Society·Elena S GusarevaMarie Lipoldová
Nov 26, 2015·Future Microbiology·Alison J EastmanMichal A Olszewski
Apr 14, 2015·Future Microbiology·Soma Rohatgi, Liise-Anne Pirofski
Mar 10, 2018·Journal of Fungi·Althea Campuzano, Floyd L Wormley
Jan 11, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Darin L WiesnerKirsten Nielsen
Nov 17, 2012·Nature Reviews. Immunology·Helene F RosenbergPaul S Foster
Oct 30, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christiane QuiniouSylvain Chemtob
Nov 24, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Soma Rohatgi, Liise-anne Pirofski
Jun 21, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ko SatoKazuyoshi Kawakami
Sep 17, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Benjamin J MurdockJohn J Osterholzer
Sep 2, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stephen J Gurczynski, Bethany B Moore
Sep 2, 2020·Infection and Immunity·Yuki SatoKazuyoshi Kawakami

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.