IL-23 inhibition for the treatment of psoriatic arthritis.

Expert Opinion on Biological Therapy
Raagav MohanakrishnanAtul Deodhar

Abstract

Introduction: Psoriatic arthritis (PsA) is a complex, polygenic immune-mediated disease with varying clinical presentations involving the skin, nails, entheses, and axial/peripheral skeleton.Areas covered: Pathophysiology of PsA with special focus on IL-23/IL-17 axis. Novel classes of targeted therapies for PsA. Pharmacologic properties, efficacy and safety of guselkumab, the only FDA approved agent from IL-23p19 inhibitor class. Data regarding other IL-23 inhibitors (Ustekinumab - an IL-12/IL-23p40 inhibitor, Risankizumab and Tildrakizumab - both IL23p19 inhibitors), in the treatment of PsA.Expert opinion: There are seven classes of FDA-approved therapies for the treatment of PsA. IL-23p19 inhibitors are the newest class of medications that has shown efficacy and reasonable safety profile in the treatment of PsA in phase 2 and phase 3 studies; Guselkumab is the only FDA-approved biologic for PsA within this class . While no head-to-head studies of IL-23p19 inhibitors and other PsA targeted therapies are available, the efficacy of these agents on musculoskeletal system appears to be comparable to TNF-inhibitors (TNFi), and the efficacy on the skin appears to be comparable, or modestly superior to the IL-17 inhibitors (IL-17i). ...Continue Reading

References

Jul 13, 2004·Arthritis and Rheumatism·Philip J MeaseWayne Tsuji
Jan 29, 2005·Annals of the Rheumatic Diseases·C AntoniUNKNOWN IMPACT 2 Trial Investigators
Feb 15, 2005·Annals of the Rheumatic Diseases·P J MeaseW J Taylor
Oct 4, 2005·Journal of the American Academy of Dermatology·Joel M GelfandTara Rolstad
Oct 4, 2005·Arthritis and Rheumatism·Philip J MeaseUNKNOWN Adalimumab Effectiveness in Psoriatic Arthritis Trial Study Group
Jan 16, 2007·Annals of the Rheumatic Diseases·Pauline Y P C HoIan N Bruce
Feb 3, 2009·Nature Clinical Practice. Rheumatology·Kristine E NogralesAnne M Bowcock
Jul 21, 2010·Archives of Dermatology·Razieh Soltani-ArabshahiGerald G Krueger
Jun 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Iannis E AdamopoulosEdward P Bowman
Sep 9, 2011·Annals of the Rheumatic Diseases·Lihi EderDafna D Gladman
May 22, 2013·Inflammatory Bowel Diseases·Esben Gjerløff Wedebye SchmidtAnders Elm Pedersen
Feb 10, 2017·Annals of the Rheumatic Diseases·Smriti K RaychaudhuriSiba P Raychaudhuri
Mar 11, 2017·Open Access Rheumatology : Research and Reviews·Salvatore D'AngeloIgnazio Olivieri
May 13, 2018·Nature Reviews. Rheumatology·Joy FeldDafna Gladman
Jun 13, 2018·Lancet·Douglas J Veale, Ursula Fearon
Aug 15, 2018·ACG Case Reports Journal·Jingzhou WangAtsushi Sakuraba
Oct 10, 2018·Annals of the Rheumatic Diseases·Stefan SiebertIain B McInnes
Oct 23, 2018·The Annals of Pharmacotherapy·Sree S KolliSteven R Feldman
Aug 30, 2019·Reumatologia·Katarzyna Banaszczyk
Sep 26, 2019·Nature Reviews. Rheumatology·Joachim SieperPierre Miossec
Jan 21, 2020·Immunological Reviews·Charlie BridgewoodDennis McGonagle
Mar 17, 2020·Best Practice & Research. Clinical Rheumatology·Maxime BrebanSimon Glatigny
May 5, 2020·Drugs in Context·Keira A FieldhouseMelinda J Gooderham

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Citations

Aug 12, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Sara CheleschiAntonella Fioravanti

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