IL-23 prevents IL-13-dependent tissue repair associated with Ly6C(lo) monocytes in Entamoeba histolytica-induced liver damage

Journal of Hepatology
Jill NollHannelore Lotter

Abstract

The IL-23/IL-17 axis plays an important role in the pathogenesis of autoimmune diseases and the pathological consequences of infection. We previously showed that immunopathologic mechanisms mediated by inflammatory monocytes underlie the severe focal liver damage induced by the protozoan parasite, Entamoeba histolytica. Here, we analyze the contribution of the IL-23/IL-17 axis to the induction and subsequent recovery from parasite-induced liver damage. IL-23p19(-/-), IL-17A/F(-/-), CCR2(-/-), and wild-type (WT) mice were intra-hepatically infected with E. histolytica trophozoites and disease onset and recovery were analyzed by magnetic resonance imaging. Liver-specific gene and protein expression during infection was examined by qPCR, microarray, FACS analysis and immunohistochemistry. Immuno-depletion and substitution experiments were performed in IL-23p19(-/-) and WT mice to investigate the role of IL-13 in disease outcome. Liver damage in infected IL-23p19(-/-), IL-17A/F(-/-), and CCR2(-/-) mice was strongly attenuated compared with that in WT mice. IL-23p19(-/-) mice showed reduced accumulation of IL-17 and CCL2 mRNA and proteins. Increased numbers of IL-13-producing CD11b(+)Ly6C(lo) monocytes were associated with disease a...Continue Reading

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Citations

Oct 26, 2018·Seminars in Immunopathology·Julie SellauHannelore Lotter
Dec 28, 2018·Circulation·Ivana ZlatanovaJean-Sébastien Silvestre
Mar 1, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shuji NakamotoMasataka Majima
Apr 9, 2021·Seminars in Immunopathology·Julie SellauHannelore Lotter
Jun 15, 2021·Journal of Hepatology·Julie SellauHannelore Lotter

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