IL-23/Th17 axis is not influenced by TNF-blocking agents in ankylosing spondylitis patients

Arthritis Research & Therapy
Fernanda Manente MilanezEloisa Bonfa

Abstract

Advances in pathophysiology and treatment of ankylosing spondylitis (AS) was recently demonstrated. However, the effect of anti-TNF in the newly described inflammatory pathways involved pathogenesis of this disease remains to be determined. The aim of our study was, therefore, to investigate long-term influence of anti-TNF drugs in IL-23/IL-17 axis of AS patients and their possible correlation with treatment, clinical, laboratory and radiographic parameters. Eighty-six AS anti-TNF naïve patients, 47 referred for anti-TNF therapy (active-AS; BASDAI ≥ 4) and 39 with BASDAI < 4 (control-AS) were included. The active group was evaluated at baseline, 12-months and 24-months after TNF blockade and compared at baseline to control-AS group and to 47 healthy age- and gender-matched controls. Plasma levels of IL-17A, IL-22, IL-23 and PGE2 were measured. Non-steroidal anti-inflammatory drugs (NSAIDs) intake were recorded every 6 months. Radiographic severity and progression was assessed by mSASSS at baseline and 24 months after therapy. At baseline, active-AS group presented higher IL-23 and PGE2 levels compared to control-AS group (p < 0.001 and p = 0.008) and to healthy controls (p < 0.001 and p = 0.02). After 24-months of TNF blockade,...Continue Reading

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Apr 28, 2017·Nature Reviews. Rheumatology·Vidya RanganathanNigil Haroon
Jun 6, 2019·Arthritis Research & Therapy·Daniel E Furst, James S Louie
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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
X-ray
ESR

Software Mentioned

SPSS

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