IL-27, targeting antigen-presenting cells, promotes Th17 differentiation and colitis in mice

Mucosal Immunology
Anabelle VisperasBooki Min

Abstract

T helper type 17 (Th17) cells have been implicated in autoimmunity and inflammatory bowel disease (IBD). Antigen-presenting cell (APC) -derived cytokines such as interleukin (IL)-1β and IL-6 are key mediators supporting Th17 differentiation, yet how these factors are induced in vivo remains unclear. Here, we show that IL-27 acting on APCs enhances IL-6 and IL-1β production and Th17 differentiation. IL-27Rα-/- T-cell receptor (TCR)β-/- recipients fail to develop gut inflammation following naive CD4 T-cell transfer, whereas IL-27Rα+/+ TCRβ-/- recipients develop severe colitis. Investigation of T-cell responses exhibits that IL-27Rα-/- TCRβ-/- mice do not support Th17 differentiation with significantly decreased levels of IL-6 and IL-1β by APCs. Our study has identified a novel proinflammatory role for IL-27 in vivo that promotes Th17 differentiation by inducing Th17-supporting cytokines in APCs.

References

Feb 12, 1998·Journal of Autoimmunity·H Ito, C G Fathman
May 29, 1998·European Journal of Immunology·I MendelM Revel
Dec 1, 2000·International Journal of Radiation Biology·A BeetzG Messer
Feb 13, 2001·European Journal of Immunology·J BrimnesM Claesson
Oct 21, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Linda HibbertRobert A Kastelein
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stefan PflanzRobert A Kastelein
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christoph HölscherStefan Ehlers
Feb 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Toshiyuki OwakiTakayuki Yoshimoto
Jan 8, 2008·Biochemical and Biophysical Research Communications·Xiao Ming FengZhong Chao Han
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Caroline DiveuRobert A Kastelein
May 19, 2009·Nature Immunology·William O'ConnorRichard A Flavell
Jul 15, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amy E TroyDavid Artis
Oct 8, 2009·Annals of Neurology·Hania KebirAlexandre Prat
Nov 17, 2009·Nature Genetics·Marcin ImielinskiHakon Hakonarson
Jan 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Céline MolleStanislas Goriely
Mar 3, 2010·Annual Review of Immunology·Jinfang ZhuWilliam E Paul
Mar 3, 2010·Annual Review of Immunology·Arthur KaserRichard S Blumberg
Nov 9, 2010·Nature Immunology·Jason S StumhoferChristopher A Hunter
Dec 22, 2010·The Journal of Experimental Medicine·Jennifer H CoxNico Ghilardi
Mar 16, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeong-su DoBooki Min
Dec 14, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christina GuzzoKatrina Gee
May 18, 2012·Cytokine & Growth Factor Reviews·Yi LiC Janneke van der Woude
May 23, 2012·Advances in Immunology·Aisling O'Hara HallChristopher A Hunter
Jan 22, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gisen KimMitchell Kronenberg
May 22, 2013·Inflammatory Bowel Diseases·Esben Gjerløff Wedebye SchmidtAnders Elm Pedersen
Aug 6, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Abhisake KoleBrian L Kelsall

❮ Previous
Next ❯

Citations

Feb 21, 2014·Seminars in Immunology·Koji Taniguchi, Michael Karin
Aug 16, 2014·Journal of Immunology Research·Anabelle VisperasBooki Min
May 7, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Christopher WynickKatrina Gee
Aug 9, 2015·Autoimmunity Reviews·Rakeshchandra R MekaKamal D Moudgil
Mar 6, 2015·Pathology Oncology Research : POR·José Veríssimo FernandesJosélio Maria Galvão de Araújo
May 26, 2016·Immunologic Research·Janette Furuzawa CarballedaJesús K Yamamoto-Furusho
Jun 1, 2016·Inflammatory Bowel Diseases·Caroline AndrewsScott K Durum
Jul 19, 2018·Inflammatory Bowel Diseases·Ross John PorterMairi Hall McLean
Apr 23, 2014·Nature Reviews. Immunology·Markus F Neurath
Apr 20, 2017·Mediators of Inflammation·Qingdong Guan, Jiguo Zhang
Feb 14, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeong-su DoBooki Min
Feb 27, 2021·International Journal of Immunopathology and Pharmacology·Xinjuan LiuXiaofeng Zeng
May 29, 2021·Experimental & Molecular Medicine·Booki MinMatthias J Feige

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
PECs
PMA
PCR
Protein Assay

Software Mentioned

Prism
FlowJo

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Jeong-su DoBooki Min
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
S Goriely, M Goldman
© 2021 Meta ULC. All rights reserved