IL-29 promoted obesity-induced inflammation and insulin resistance.

Cellular & Molecular Immunology
Tian-Yu LinYu-Hsiang Hsu

Abstract

Adipocyte-macrophage crosstalk plays a critical role to regulate adipose tissue microenvironment and cause chronic inflammation in the pathogenesis of obesity. Interleukin-29 (IL-29), a member of type 3 interferon family, plays a role in host defenses against microbes, however, little is known about its role in metabolic disorders. We explored the function of IL-29 in the pathogenesis of obesity-induced inflammation and insulin resistance. We found that serum IL-29 level was significantly higher in obese patients. IL-29 upregulated IL-1β, IL-8, and monocyte chemoattractant protein-1 (MCP-1) expression and decreased glucose uptake and insulin sensitivity in human Simpson-Golabi-Behmel syndrome (SGBS) adipocytes through reducing glucose transporter 4 (GLUT4) and AKT signals. In addition, IL-29 promoted monocyte/macrophage migration. Inhibition of IL-29 could reduce inflammatory cytokine production in macrophage-adipocyte coculture system, which mimic an obese microenvironment. In vivo, IL-29 reduced insulin sensitivity and increased the number of peritoneal macrophages in high-fat diet (HFD)-induced obese mice. IL-29 increased M1/M2 macrophage ratio and enhanced MCP-1 expression in adipose tissues of HFD mice. Therefore, we have ...Continue Reading

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Citations

Jan 22, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Liliya V VasilevaMilen I Georgiev
May 26, 2021·Anais Brasileiros De Dermatologia·Li-Xin FuPei-Mei Zhou
Sep 13, 2021·Molecular Nutrition & Food Research·Tariful IslamNaima Moustaid-Moussa

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Methods Mentioned

BETA
ELISA
FACS
SGBS
enzyme-linked
PMA
flow cytometry
PECs
PCR
Assay

Software Mentioned

Prism
GraphPad

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