IL-3, IL-4, and IL-6 enhance IFN-gamma-dependent bone marrow natural suppressor activity

Cellular Immunology
J H HoldaH N Claman

Abstract

The ability of murine bone marrow (BM) natural suppressor (NS) cells to suppress a Con A proliferation assay was greatly enhanced by supernatant obtained from the T cell hybridoma D9C1.12.17. Of the lymphokines produced by this hybridoma, three were found to enhance suppression: interleukin-3 (IL-3), IL-4, and IL-6. These molecules enhanced suppression of both unirradiated and irradiated (2000 R) BM cells indicating that augmented suppression was not just due to proliferation of NS cells. The ability of all three of the lymphokines to enhance BM suppression could be blocked by anti-interferon-gamma (IFN-gamma) antibody. These results indicate that (1) NS cell activity is not radiosensitive and (2) that two signals may be required for maximal NS cell suppression, one being a lymphokine-mediated signal and the other IFN-gamma.

References

Sep 1, 1988·Immunology Today·K Bottomly
May 1, 1988·Immunology Today·G G Wong, S C Clark
Feb 1, 1985·European Journal of Immunology·S MoreckiS Slavin
Jul 1, 1985·The Journal of Experimental Medicine·R B SchwadronS Strober
Jan 1, 1987·The Journal of Experimental Medicine·Y HamaguchiY Kitamura
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A ZlotnikM Howard
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K IkebuchiM Ogawa
May 1, 1982·The American Journal of Anatomy·K Dorshkind, C Rosse
Feb 1, 1980·Cellular Immunology·J S CorveseS R Cooperband
Oct 1, 1986·Immunology Today·T MaierH N Claman

Citations

Apr 6, 1999·Biulleten' eksperimental'noĭ biologii i meditsiny·V I SeledtsovE A Kashchenko
Aug 7, 1998·Biulleten' eksperimental'noĭ biologii i meditsiny·V I SeledtsovV A Kozlov
Jun 19, 1998·Biulleten' eksperimental'noĭ biologii i meditsiny·V I SeledtsovV A Kozlov
May 1, 1995·Developmental and Comparative Immunology·M R JadusH T Wepsic
Feb 15, 2003·International Immunopharmacology·Kristi A HaskinsJ H Holda

Related Concepts

Metazoa
Marrow
Interferon Type II
Interleukin-3
Mice, Inbred BALB C
Proteins, Recombinant DNA
Interleukin-4
Interleukin-6
Tr1 Cells
Mouse, Swiss

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.

Related Papers

Biulleten' eksperimental'noĭ biologii i meditsiny
D M SamarinV A Kozlov
Developmental and Comparative Immunology
B E Barton
Immunologic Research
A Butturini, R P Gale
© 2021 Meta ULC. All rights reserved