IL-33 Drives Eosinophil Infiltration and Pathogenic Type 2 Helper T-Cell Immune Responses Leading to Chronic Experimental Ileitis

The American Journal of Pathology
Carlo De SalvoTheresa T Pizarro

Abstract

Although a clear association has been established between IL-33 and inflammatory bowel disease, mechanistic studies to date, primarily using acute murine models of colitis, have yielded contradicting results, demonstrating both pathogenic and protective roles. We used a well-characterized, spontaneous model of inflammatory bowel disease [ie, SAMP1/YitFc (SAMP) mice] to investigate the role of IL-33 during chronic intestinal inflammation. Our results showed marked eosinophil infiltration into the gut mucosa with increased levels of eotaxins and type 2 helper T-cell (Th2) cytokines as disease progressed and became more severe, which could be reversed upon either eosinophil depletion or blockade of IL-33 signaling. Exogenous IL-33 administration recapitulated these effects in ilea of uninflamed (parental) control AKR/J mice. Human data supported these findings, showing colocalization and up-regulation of IL-33 and eosinophils in the colonic mucosa of inflammatory bowel disease patients versus noninflamed controls. Finally, colonization of commensal flora by fecal material transplantation into germ-free SAMP and the presence of the gut microbiome induced IL-33, subsequent eosinophil infiltration, and mounting of Th2 immune response...Continue Reading

References

Jun 22, 1999·The Journal of Clinical Investigation·A MishraM E Rothenberg
Mar 20, 2001·The Journal of Clinical Investigation·M M KosiewiczF Cominelli
Feb 18, 2003·The Journal of Allergy and Clinical Immunology·Nives ZimmermannMarc E Rothenberg
May 27, 2004·European Journal of Immunology·Hidetoshi TakedatsuMichio Sata
Mar 1, 2006·The Journal of Experimental Medicine·Timothy S OlsonTheresa T Pizarro
Dec 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Virginie CarriereJean-Philippe Girard
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Giorgos BamiasFabio Cominelli
Apr 4, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Simon P HoganMarc E Rothenberg
Aug 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Damo XuFoo Y Liew
Sep 20, 2008·Journal of Leukocyte Biology·Maria LampinenMarie Carlson
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mariola Kurowska-StolarskaDamo Xu
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Richard AhrensSimon P Hogan
Feb 28, 2009·Arthritis and Rheumatism·Gaby PalmerCem Gabay
Apr 7, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Cheryl ProtheroeJames J Lee
Nov 17, 2009·Immunology Letters·Jakob Benedict SeidelinOle Haagen Nielsen
Dec 17, 2009·Inflammatory Bowel Diseases·Caroll J BeltránMarcela A Hermoso
Mar 5, 2010·Nature·Daniel R NeillAndrew N J McKenzie
Apr 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Luca PastorelliTheresa T Pizarro
Apr 21, 2010·Journal of Gastroenterology·Ayako KoboriAkira Andoh
Aug 10, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bartosz StolarskiFoo Y Liew
Oct 13, 2010·Proceedings of the National Academy of Sciences of the United States of America·Keisuke ObokiSusumu Nakae
May 11, 2011·Inflammatory Bowel Diseases·Theresa T PizarroFabio Cominelli
Jun 15, 2011·International Journal of Molecular Medicine·Hirotsugu ImaedaYoshihide Fujiyama
Sep 29, 2011·The American Journal of Pathology·Joanne C MastersonGlenn T Furuta
Apr 18, 2012·Inflammatory Bowel Diseases·Philipp GroβClaudia Hofmann
Dec 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Li-Yin HungDe'Broski R Herbert
Apr 16, 2013·Immunology·Peter N PushparajDamo Xu
Aug 2, 2013·Journal of Leukocyte Biology·Maria LampinenSimon P Hogan
Aug 21, 2013·Immunity·Tamar McHedlidzeStefan Wirtz
Sep 17, 2013·Nature·Jesse C NussbaumRichard M Locksley
Dec 18, 2013·European Journal of Immunology·Paolo BiancheriThomas T MacDonald
Jul 22, 2014·Nature·Chris SchieringFiona Powrie
Dec 17, 2014·European Journal of Immunology·Masaaki HashiguchiTetsuji Kobata
May 15, 2015·Nature Reviews. Gastroenterology & Hepatology·Rimma GoldbergNick Powell
Aug 6, 2015·Proceedings of the National Academy of Sciences of the United States of America·Laurel A MonticelliDavid Artis

❮ Previous
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Citations

Dec 4, 2016·Annual Review of Immunology·Toshinori NakayamaYoshitaka Okamoto
Jan 11, 2017·Journal of Gastroenterology and Hepatology·Jun Tao LuZhi Hua Ran
Feb 2, 2017·Inflammatory Bowel Diseases·Loris R LopetusoTheresa T Pizarro
Feb 16, 2017·Gut·Christine P PetersenJames R Goldenring
Dec 9, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeong-Su DoBooki Min
Jan 11, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Catherine H Plunkett, Cathryn R Nagler
Jul 19, 2018·Inflammatory Bowel Diseases·Ross John PorterMairi Hall McLean
Mar 2, 2018·Scientific Reports·Alexander Rodriguez-PalaciosFabio Cominelli
Mar 12, 2019·Inflammatory Bowel Diseases·Rhiannon T FilipponeKulmira Nurgali
Oct 18, 2016·Current Opinion in Gastroenterology·Giorgos Bamias, Fabio Cominelli
Aug 24, 2020·Journal of Leukocyte Biology·Rodrigo Emanuel Hernández Del PinoVirginia Pasquinelli
Sep 19, 2018·Proceedings of the National Academy of Sciences of the United States of America·Loris R LopetusoTheresa T Pizarro
Sep 3, 2019·Frontiers in Pharmacology·Hyosun JangJae Kyung Myung
May 10, 2020·Inflammatory Bowel Diseases·Daniele CorridoniAlison Simmons
Jan 7, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer DuffenMarion Kasaian
Nov 9, 2018·Frontiers in Immunology·Ourania S KotsiouSotirios G Zarogiannis
Sep 10, 2020·Cancer Management and Research·Xujun ZhangHongyan Diao
Apr 20, 2017·Mediators of Inflammation·Qingdong Guan, Jiguo Zhang
Oct 24, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yoshiyuki MishimaYoshikazu Kinoshita
Apr 1, 2018·Journal of Leukocyte Biology·Maria LampinenMarie Carlson
May 30, 2019·Frontiers in Immunology·Michelle A WilliamsSinéad C Corr
May 16, 2020·Mediators of Inflammation·Xiuzhu GaoJunqi Niu
Sep 5, 2020·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Yu-Hsuan LinChia-Hung Kao
Feb 2, 2021·Immunological Investigations·Faezeh RamezaniHamed Mohammadi
Sep 20, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Giorgos Bamias, Fabio Cominelli
Jan 15, 2021·The Journal of Clinical Investigation·Carlo De SalvoTheresa T Pizarro
Mar 28, 2021·Seminars in Immunopathology·G CoakleyN L Harris
Mar 2, 2021·Annual Review of Immunology·Elizabeth A JacobsenMarc E Rothenberg
Nov 19, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melvin ZhangMarion T Kasaian

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