IL-33 inhibits RANKL-induced osteoclast formation through the regulation of Blimp-1 and IRF-8 expression

Biochemical and Biophysical Research Communications
Hiroyasu KiyomiyaTatsuji Nishihara

Abstract

Interleukin (IL)-33 is a recently discovered proinflammatory cytokine that belongs to the IL-1 family. Several studies have reported that IL-33 inhibits osteoclast differentiation. However, the mechanism of IL-33 regulation of osteoclastogenesis remains unclear. In the present study, we examined the effect of IL-33 on osteoclast formation in vitro. IL-33 suppressed osteoclast formation in both mouse bone marrow cells and monocyte/macrophage cell line RAW264.7 cells induced by receptor activator of NF-κB ligand (RANKL) and/or macrophage stimulating factor (M-CSF). IL-33 also inhibited the expression of RANKL-induced nuclear factor of activated T-cell cytoplasmic 1 (NFATc1), thereby decreasing the expression of osteoclastogenesis-related marker genes, including Cathepsin K, Osteoclast stimulatory transmembrane protein (Oc-stamp) and Tartrate-resistant acid phosphatase (Trap). Blockage of IL-33-ST2 binding suppressed the IL-33-mediated inhibition of NFATc1. RANKL-induced B-lymphocyte-induced maturation protein-1 (Blimp-1) expression was also suppressed by IL-33, which was followed by the stimulation of anti-osteoclastic genes such as interferon regulatory factor-8 (IRF-8). These results suggest that IL-33-ST2 interactions down-reg...Continue Reading

References

Nov 9, 2005·The Journal of Experimental Medicine·Masataka AsagiriHiroshi Takayanagi
Mar 24, 2007·Nature Reviews. Immunology·Hiroshi Takayanagi
Sep 14, 2007·European Journal of Immunology·Mousa Komai-KomaFoo Y Liew
Mar 29, 2008·Annual Review of Immunology·Gislâine Martins, Kathryn Calame
Feb 28, 2009·Arthritis and Rheumatism·Gaby PalmerCem Gabay
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Keizo NishikawaHiroshi Takayanagi
Oct 13, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jochen SchulzeThorsten Schinke
Dec 7, 2011·Biochemical and Biophysical Research Communications·Johannes KellerThorsten Schinke
Feb 18, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hiroya MiyamotoTakeshi Miyamoto
Aug 16, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kyung-Hyun Park-MinLionel B Ivashkiv

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Citations

Oct 21, 2015·Seminars in Cell & Developmental Biology·Anita T Shaw, Ellen M Gravallese
Mar 16, 2016·BioMed Research International·N LampiasiF Zito
Nov 26, 2015·The American Journal of Pathology·Izabella L A LimaTarcília A Silva
Jan 21, 2017·Journal of Cellular Physiology·Wataru AriyoshiTatsuji Nisihara
Mar 25, 2020·Medicina·Massimo De MartinisCarmen Mannucci
Mar 6, 2018·Immune Network·Dulshara Sachini AmarasekaraJaerang Rho
Jul 28, 2020·International Journal of Molecular Sciences·Hideki KitauraItaru Mizoguchi
Mar 9, 2019·Scientific Reports·Lia GinaldiSebastiano Gangemi
Feb 13, 2020·International Journal of Molecular Sciences·Fumitoshi OhoriItaru Mizoguchi
Feb 20, 2020·International Journal of Molecular Sciences·Massimo De MartinisLia Ginaldi
Jan 26, 2021·Frontiers in Immunology·Massimo De MartinisSebastiano Gangemi
Apr 23, 2021·Arthritis Research & Therapy·Kyoung-Woon KimHae-Rim Kim

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