IL-33 promotes recovery from acute colitis by inducing miR-320 to stimulate epithelial restitution and repair

Proceedings of the National Academy of Sciences of the United States of America
Loris R LopetusoTheresa T Pizarro

Abstract

Defective and/or delayed wound healing has been implicated in the pathogenesis of several chronic inflammatory disorders, including inflammatory bowel disease (IBD). The resolution of inflammation is particularly important in mucosal organs, such as the gut, where restoration of epithelial barrier function is critical to reestablish homeostasis with the interfacing microenvironment. Although IL-33 and its receptor ST2/ILRL1 are known to be increased and associated with IBD, studies using animal models of colitis to address the mechanism have yielded ambiguous results, suggesting both pathogenic and protective functions. Unlike those previously published studies, we focused on the functional role of IL-33/ST2 during an extended (2-wk) recovery period after initial challenge in dextran sodium sulfate (DSS)-induced colitic mice. Our results show that during acute, resolving colitis the normal function of endogenous IL-33 is protection, and the lack of either IL-33 or ST2 impedes the overall recovery process, while exogenous IL-33 administration during recovery dramatically accelerates epithelial restitution and repair, with concomitant improvement of colonic inflammation. Mechanistically, we show that IL-33 stimulates the expressi...Continue Reading

References

Nov 13, 2004·The New England Journal of Medicine·Fabio Cominelli
Mar 1, 2006·The Journal of Experimental Medicine·Timothy S OlsonTheresa T Pizarro
Dec 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Virginie CarriereJean-Philippe Girard
Jun 9, 2007·The Journal of Clinical Investigation·Franco ScaldaferriSilvio Danese
Jul 12, 2007·The Journal of Biological Chemistry·Hiroko HayakawaShin-ichi Tominaga
Aug 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alissa A ChackerianRobert A Kastelein
May 15, 2009·Proceedings of the National Academy of Sciences of the United States of America·Corinne Cayrol, Jean-Philippe Girard
Nov 17, 2009·Immunology Letters·Jakob Benedict SeidelinOle Haagen Nielsen
Dec 17, 2009·Inflammatory Bowel Diseases·Caroll J BeltránMarcela A Hermoso
Apr 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Luca PastorelliTheresa T Pizarro
Apr 21, 2010·Journal of Gastroenterology·Ayako KoboriAkira Andoh
Jul 28, 2010·Nature Reviews. Genetics·Jacek KrolWitold Filipowicz
May 11, 2011·Inflammatory Bowel Diseases·Theresa T PizarroFabio Cominelli
Apr 18, 2012·Inflammatory Bowel Diseases·Philipp GroβClaudia Hofmann
Jul 13, 2013·Frontiers in Immunology·Loris R LopetusoTheresa T Pizarro
Jul 22, 2014·Nature·Chris SchieringFiona Powrie
Jul 27, 2014·Current Opinion in Pharmacology·Lan Xiao, Jian-Ying Wang
Jul 16, 2015·Mucosal Immunology·G LeoniA Nusrat
Aug 6, 2015·Proceedings of the National Academy of Sciences of the United States of America·Laurel A MonticelliDavid Artis
Nov 22, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Oscar Medina-ContrerasTimothy L Denning
Oct 27, 2016·Nature Reviews. Immunology·Foo Yew LiewHeth Roderick Turnquist
Jul 16, 2017·Scientific Reports·Zhengxiang HeSergio A Lira
May 16, 2018·Proceedings of the National Academy of Sciences of the United States of America·Vu L NgoTimothy L Denning

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Citations

Dec 12, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amanda WaddellMichael J Rosen
Apr 24, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Viviani MendesAngelica Thomaz Vieira
Aug 3, 2019·Expert Opinion on Biological Therapy·Irene MarafiniGiovanni Monteleone
Feb 23, 2020·Expert Opinion on Biological Therapy·Loris R LopetusoGiovanni Cammarota
May 30, 2019·Frontiers in Immunology·Michelle A WilliamsSinéad C Corr
Oct 7, 2019·Inflammatory Bowel Diseases·Olga Maria NardoneMarietta Iacucci
Nov 9, 2019·Cell Death & Disease·Lester ThooPhilippe Krebs
Jul 12, 2020·Nature Reviews. Gastroenterology & Hepatology·Jay V Patankar, Christoph Becker
Nov 16, 2019·Molecular Nutrition & Food Research·Haider Rasheed AlrafasPrakash S Nagarkatti
Jun 18, 2020·Frontiers in Immunology·Cristina LecchiFabrizio Ceciliani
Apr 10, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Jiguang ZhangXing Lin
May 10, 2020·Inflammatory Bowel Diseases·Daniele CorridoniAlison Simmons
Jul 23, 2020·Frontiers in Immunology·Caroline ChauchéHenry J McSorley
Aug 5, 2020·Nature Medicine·Daniele CorridoniAlison Simmons
Sep 11, 2020·Cells·Gloria Pastor-FernándezMaría N Navarro
Nov 28, 2020·The American Journal of Pathology·Li-Yin HungDe'Broski R Herbert
Jan 20, 2021·Pharmacological Reports : PR·Zengping KangDuanyong Liu
Oct 22, 2019·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Lu Liu, Xiaohua Li
Feb 2, 2021·Immunological Investigations·Faezeh RamezaniHamed Mohammadi
Dec 31, 2020·Mediators of Inflammation·Fernando BotelhoCarl D Richards
Feb 28, 2021·Genes & Genomics·Sabrina Ka Man Tam, Danny Chi Yeu Leung
Jan 15, 2021·The Journal of Clinical Investigation·Carlo De SalvoTheresa T Pizarro
Mar 28, 2021·Mucosal Immunology·Noëmie DanielBenoit Chassaing
Apr 5, 2021·Auris, Nasus, Larynx·Paulina AdamczykJarosław Szydłowski
May 1, 2021·Journal of Personalized Medicine·Alfredo CesarioGiovanni Scambia
May 18, 2021·Therapeutic Advances in Gastroenterology·Giuseppe PriviteraAlessandro Armuzzi
Jun 3, 2021·International Journal of Molecular Sciences·Laura Francesca PisaniLuca Pastorelli
Jun 15, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Cambrian Y LiuEugene B Chang

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