IL-33/s-ST2 ratio, systemic symptoms, and basophil activation in Pru p 3-sensitized allergic patients

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
Carina G UasufElisabetta Pace

Abstract

Although IL-33/ST2 axis is involved in the development of allergic diseases, its contribution in food allergy is still unknown. In this study, we assessed the serum levels of IL-33 and its s-ST2 receptor in 53 control patients (without allergic diseases), 47 peach (Pru p 3)-sensitized allergic patients (SAP), and in 68 non-Pru p 3-SAP. Basophil activation test (BAT) was used to assess the basophil activation due to allergen exposure before and after the addition of s-ST2 to the blood samples from 5 Pru p 3-SAP. IL-33 levels in Pru p 3-SAP were higher than in non-Pru p 3-SAP and in normal controls. Lower s-ST2 levels were found in Pru p 3-SAP than in non-Pru p 3-SAP. IL-33/s-ST2 ratio was higher in Pru p 3-SAP than in both non-Pru p 3-SAP and controls. Higher IL-33/s-ST2 ratio was observed in Pru p 3-SAP with severe than in those with mild systemic symptoms. BAT analysis in Pru p 3-SAP showed a decrease in basophil activation due to Pru p 3 exposure after the addition of s-ST2 to the blood samples. An imbalance in the baseline levels of IL-33/ST2 pathway is present in Pru p 3-SAP. The measurement of this pathway might be helpful to detect patients at a higher risk of developing severe systemic symptoms.

References

Dec 3, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·G W Canonica, G Ciprandi
Sep 4, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·William W Storms
Aug 8, 2006·The Journal of Allergy and Clinical Immunology·Montserrat Fernández-RivasRonald van Ree
May 10, 2007·Current Opinion in Allergy and Clinical Immunology·Laurian Zuidmeer, Ronald van Ree
Jun 6, 2009·International Archives of Allergy and Immunology·R AseroG E Senna
Oct 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·David PréfontaineQutayba Hamid
Jan 19, 2010·Nature Reviews. Immunology·Foo Y LiewIain B McInnes
Jan 19, 2010·Nature Reviews. Immunology·John E Sims, Dirk E Smith
Feb 16, 2010·The Journal of Allergy and Clinical Immunology·David PréfontaineQutayba Hamid
Jun 29, 2010·Current Allergy and Asthma Reports·Matthias EggerGabriele Gadermaier
Jul 31, 2010·Mediators of Inflammation·Jyh-Hong LeeBor-Luen Chiang
Jan 12, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R KamekuraT Himi
Feb 22, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Joanna GlückBarbara Rogala
Aug 24, 2012·Allergy·Tatsukuni OhnoSusumu Nakae
Sep 26, 2012·The Journal of Allergy and Clinical Immunology·Derek K ChuManel Jordana
Feb 27, 2014·Journal of the American Academy of Dermatology·Risa Tamagawa-MineokaNorito Katoh
Jun 17, 2014·Biochimica Et Biophysica Acta·Elisabetta PaceMark Gjomarkaj
Aug 13, 2014·The Journal of Allergy and Clinical Immunology·Yih-Chih ChanHannah J Gould
Sep 13, 2014·Journal of Pharmacological Sciences·Takeshi Nabe
Oct 9, 2014·The Journal of Clinical Investigation·Leticia TordesillasM Cecilia Berin
Dec 3, 2014·The Journal of Allergy and Clinical Immunology·Paul E PfefferCatherine M Hawrylowicz
Aug 11, 2015·European Journal of Immunology·Geethani BandaraDean D Metcalfe
Aug 12, 2015·The Journal of Allergy and Clinical Immunology·Jennifer J KoplinUNKNOWN HealthNuts Study
Nov 24, 2016·The Journal of Allergy and Clinical Immunology·Régis JouliaEric Espinosa
May 10, 2017·Frontiers in Immunology·Brad Griesenauer, Sophie Paczesny

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Citations

Oct 23, 2019·Expert Review of Clinical Immunology·Andrea MatucciAlessandra Vultaggio
Jun 27, 2020·Current Opinion in Allergy and Clinical Immunology·Andrea MatucciEnrico Maggi

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Methods Mentioned

BETA
ELISA
flow cytometry

Software Mentioned

FACSCalibur
CellQuest

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